Innate Immune System - Pathway Page
Name Innate Immune System
Resource Reactome
Genes CLEC4C DEFB121 ITGAX COPB1 JUN PIK3CA PRKCSH GLA TXNDC5 TREX1 LAMP1 IGKV3-15 MASP2 TTR C5AR1 CPNE3 PRG3 PPP3CB DEFB112 CGAS RAB7A RAB5C IKBKB MYH2 IGHG4 DEFA4 BCL10 CXCL1 MCEMP1 MUC12 PTPN6 NIT2 FBXW11 TBC1D10C ADAM10 ATP6V1F CYBA VAT1 LAT FABP5 C1QC SHC1 MAN2B1 FGB RAB24 PI3 POLR3D SLC2A3 ATP7A RAB37 PIK3R1 HRNR GOLGA7 CD14 PPBP BCL2 UBE2D1 NOS3 DEGS1 CKAP4 CD59 HMGB1 IQGAP2 PRDX4 AGPAT2 DEFB104A PSMD1 LILRB3 AOC1 ARHGAP45 CFHR5 ROCK1 PLCG2 PSMA3 IDH1 RAF1 C1orf35 DNM1 GPI PAK1 PSMD7 ADAM8 FCGR3A POLR3C CLEC4D TMC6 ECSIT PLPP4 DEFB1 SLC44A2 ORM1 HLA-B CDC34 DEFB106A IGKV3-20 NLRC5 FGR PSMA4 BIRC3 NOD2 PPP3CA RPS27A ITK SIRPB1 PRKCE ATP6V1C2 DSC1 MGST1 MAPK1 TMBIM1 ITLN1 C4BPB RAB14 RAB27A GRAP2 CYLD IRF7 CD44 ATG5 DDOST FRK PSMB3 SELL P2RX1 LCN2 ATF1 IGHV2-5 LRRFIP1 HBB FTL IGKV2D-40 GALNS ACTG1 NEU1 POLR3G ACLY PIK3R2 OTUD5 B4GALT1 DEFB108A SERPINB10 RAB3D UBE2D2 ANPEP ICAM2 ATP6V0E2 EPPIN MASP1 DBNL SERPINA1 S100P ABI2 GCA DOCK1 IGLV1-44 UBR4 NPC2 BPIFA2 LPCAT1 CHIT1 IGHV1-46 XRCC5 CFP NFKBIA TLR9 MYO5A SERPING1 PSMD5 HEXB CDC42 POLR3K CD247 DHX58 KPNB1 CCR2 HERC5 NCF1 MANBA HPSE IGLV3-1 C9 YPEL5 POLR2E IFNA10 IFNA4 RNASE7 DNAJC13 IGKV4-1 DEFB135 PSMB7 NCF4 ARHGAP9 PSME2 DEFB136 PRCP HSPA6 SYK PSAP NCR2 LAT2 ANXA2 ATP6AP2 CYFIP1 CLU IGKV1-12 PSMD8 CR1 CAT PSMD4 C8G ARPC4 RAB31 SEM1 PRKACB TARM1 ITGAM PA2G4 ADGRE3 IGHV1-2 IGLV2-11 NLRC4 NLRX1 GRN IGLV3-25 PLCG1 DSP IGLV1-51 CLEC5A C4B IGHV2-70 ATP6V0E1 A1BG EP300 F2 MMP8 RHOA WASF1 DERA CRK IGHV3-11 ITGB2 CREG1 GM2A ATP11B SIRPA BIN2 RAB18 UBB IMPDH1 DNAJC5 CYBB ARPC5 MAPK8 ATP6V0D1 IGLV3-27 NRAS ACTR3 ATP6V1G3 CD209 DEFA6 BPI SRC AGA CMTM6 GZMM UBE2K VAMP8 TLR3 HK3 PTPRJ IGKV1-33 S100A7A FCAR ARG1 LBP BPIFA1 FPR1 CASP1 NLRP3 DHX36 STOM DEFB130A NLRC3 CAP1 RPS6KA2 MAP2K1 TNFAIP3 CD47 APAF1 MUC5AC TCIRG1 STBD1 PSMD12 ATP6V0A4 CREB1 ATP6V1B2 RAP1B ATP8A1 SERPINB6 RAP2C NCKAP1 S100A12 DEFB116 MUC20 DDX3X TAX1BP1 KCNAB2 IMPDH2 POLR2F GRB2 TNFRSF1B DUSP4 TSPAN14 CALM1 LRRC7 HSPA8 GYG1 CTSH PSMA5 MRE11 RNASE6 ARSA LRG1 TUBB SFTPD CTSV APEH ENPP4 AGL GSDMD CSNK2B FAF2 GGH NFASC CDA DEFA5 NHLRC3 IGKC NLRP1 SIGIRR PSMC6 KIR2DS4 CR2 DYNC1LI1 IGHV3-13 DEFB128 ATAD3B CD68 LGALS3 SERPINB1 POLR3B DYNLL1 NFKBIB EEA1 CFHR1 RPS6KA1 MAPK14 PSEN1 PTPN11 IGKV1-17 NCSTN VAV1 CEACAM3 RNASE2 KIR2DS1 ITCH C1QA PSMC3 SLPI CD53 TCN1 DYNLT1 TEC DEFB110 RASGRP4 MOSPD2 DNM2 RAB10 DYNC1H1 ITGAV CRP PSMA1 POLR1C EPX MEFV SLC27A2 DUSP6 DTX4 FGA LYN DSN1 CD36 ILF2 IGLV3-21 MAPK13 PGLYRP3 MUC2 IGKV2-28 IFNA6 PSMD11 VTN RIPK1 C6 TYROBP EEF2 DEFB113 ERP44 RHOF IL1B IFNA17 DUSP7 MYD88 PSMC5 PSMB5 PADI2 DSG1 ACAA1 CTSS ACTR10 PSTPIP1 PGLYRP1 TBK1 ATP6V1G2 C4BPA DEFA3 SDCBP PSMD14 DEFB108B NFAM1 IGLC1 ATP8B4 LILRA3 BPIFB1 IFNA14 HCK TXN ATP6V0A2 PPP3R1 CD63 IGHV4-59 PSMF1 FPR2 NCKAP1L PPP2R5D CFHR3 OSCAR SLC2A5 DEFB134 TRIM56 PROS1 NF2 GLB1 CPPED1 HTN1 POLR2K WAS C7 AP1M1 TAB2 IGKV1-5 IGHG1 SVIP METTL7A CFHR2 DEFB133 TIMP2 MME DEFB124 PNP ISG15 PDAP1 UBC IGHV4-34 MAPK9 RBSN RNF135 PGM2 MMP9 IGLV3-19 ADGRG3 S100A9 DNM3 MNDA CXCR1 NDUFC2 PLAUR CARD9 MYO10 BRI3 SERPINB12 CCR6 IGKV1D-33 CFHR4 ARPC1A PSMB1 ATP6V1A UNC93B1 TXNIP FCN3 FCN1 TIRAP SIGLEC14 FADD DEFB123 ATP6V0C CXCR2 IRAK3 ZBP1 ALDOC UBE2D3 ACTR1B CHRNB4 PIN1 LILRB2 MAPKAPK3 CFH ORM2 CTSK OSTF1 POLR3A MAP3K7 PSMC1 PYGB ARL8A IGF2R MAPK12 JUP BST1 FUCA2 QSOX1 ADGRE5 DEFB103A GDI2 KCMF1 CD4 CNPY3 MAP2K4 LCK LAMTOR2 PSME1 IGKV1-39 ARPC1B RAB4B IFNB1 ADA2 PPP2CA PGAM1 ARPC2 IRAK4 QPCT PGLYRP4 POLR2H RASGRP1 IGLC6 C1QB PTPN4 CASP9 KIR3DS1 GHDC IGKV2-30 COMMD3 CAPZA2 IKBKE PTX3 ITPR1 WIPF2 KRAS NAPRT C8B PLD4 SURF4 ATP6V1B1 MUC7 FLG2 PDZD11 SIGLEC15 ALAD AP2A2 HSP90AB1 IGHV3-48 LEAP2 DDX41 PIK3R4 PLA2G2A ACTR2 CD300LB MUC17 CLEC7A MYO1C ATP11A RIPK3 SOCS1 ATP6V1G1 ACPP PTPRN2 RAP1A TRIM32 ITGAL IGLV6-57 P2RX7 NOS1 UNC13D LTF NOS2 C1R PSMA2 SRP14 NFKB1 MIF DEFB132 KRT1 CEACAM8 GPR84 SLC15A4 RIPK2 TAB1 PCBP2 SFTPA2 OLR1 PSMD10 HLA-A DDX58 CLEC6A ICAM3 PECAM1 STK10 IFNA2 FOLR3 PAK2 PRKACG COMMD9 SERPINA3 XRCC6 CREBBP PRSS3 ATP6V0D2 CD46 ATOX1 MUC13 PSMC2 PELI2 UBA7 TLR10 LAMTOR1 SOS1 CD93 RAB9B GLIPR1 FRMPD3 BIRC2 PSMB6 CANT1 CEACAM6 HTN3 PSME3 IRF3 C6orf120 ATP6V1E1 NCF2 OLFM4 ELMO1 MPO NLRP4 HVCN1 PFKL CTSD SIKE1 MAP3K8 NKIRAS2 PTGES2 MAP3K1 S100A1 MALT1 PRG2 ASAH1 DEFB105A LY86 CRCP RAB44 PRKACA PLA2G6 IGHV3-7 MAP3K14 WASF2 CD180 DCD CPN2 IGHV3-30 MAPKAPK2 CD55 C5 VAV2 ARSB FGG BRK1 MYO9B IGKV1D-12 MEF2C CARD11 CTSL CSTB CEP290 HLA-H IGHV3-9 MUC3A VNN1 CPNE1 RELA DGAT1 DOK3 GNS CD300A DOCK2 NFKB2 NFATC2 SIGLEC5 KIR2DS5 SAA1 TRAPPC1 FCER1A IGKV2D-28 BTRC SIGLEC16 LY96 SNAP29 DEFB4A MLEC ACTB STK11IP HEBP2 DIAPH1 S100A8 KLRD1 ATP6V1C1 ATP6V1E2 PRKCD NOD1 CTSZ SIGLEC9 KLRK1 S100A11 B2M FTH1 RNF216 CAPN1 RPS6KA5 POLR3E PLAC8 PRDX6 PTPRC RETN MYH9 GSN PGRMC1 UBA52 PGM1 PIK3C3 ORMDL3 S100A7 ATF2 PSMB8 DEFB127 CASP10 AMPD3 NFATC1 PELI3 CAB39 VCP TMEM63A CD58 PPIE IGKV3D-20 DPP7 PLD2 EEF1A1 MS4A2 STAT6 TANK HSPA1A C5AR2 TREM1 LGMN AIM2 MUC6 IFNA5 C2 IFI16 LYZ UBE2L6 SYNGR1 PSME4 DEFB130B CTSC SPTAN1 POLR2L MUC16 TRAF6 COLEC10 NKIRAS1 MGAM ARPC3 IFIH1 PAFAH1B2 C8A DEFB131A NFATC3 SCAMP1 LAMP2 CNN2 LAIR1 RHOG LCP2 CRISPLD2 PLD3 IFNA7 CST3 TLR7 VAPA IGKV3-11 GAB2 ALDOA WIPF3 PSMB10 CHI3L1 IGKV1D-39 REG3G HSPA1B ABL1 CTNNB1 SNAP23 VAV3 POLR3F DUSP3 FGL2 MUC1 BPIFB4 CYSTM1 BTK MUC3B RAB3A IKBKG DEFB129 PTK2 TMEM179B IGLV1-40 RAB5B DNASE1L1 NCKIPSD TRAF3 C4A UBE2V1 TLR1 HP RAC1 CEACAM1 CHUK MAGT1 PSMD6 PSMA6 SLC11A1 HRAS LTA4H BPIFB6 MEF2A CDK13 PSMC4 ANO6 PPIA C1S CD3G ELANE CASP4 MUC15 APP ELMO2 CPB2 CTSB LAMTOR3 DHX9 IFNA16 IGKV2D-30 FOS IGKV1-16 IGHE CAPZA1 TUBB4B TXK PYGL IGHV4-39 WASF3 HLA-C CYFIP2 PRKDC CRACR2A DEFA1 ATG7 MAPK11 FYN IGKV5-2 UBE2M PAK3 ATP6V0A1 MUC19 CASP8 IQGAP1 RNASET2 ELK1 PPP2R1B IGKV2-29 TLR6 AHCYL1 TNIP2 RAP2B CFB PELI1 PRKCQ PRTN3 BPIFB2 PSMD2 PLEKHO2 CLEC4A CHGA CYB5R3 PDXK COTL1 CLEC4E TOM1 GNLY IGLV2-14 MAPK3 TMEM30A BAIAP2 WIPF1 ATP6V1D PANX1 NME2 ALDH3B1 PKP1 APRT IGKV1D-16 PSMB2 CPN1 PSMD3 UBE2N CLEC10A CTSA SLCO4C1 PSMA7 GMFG BST2 TOLLIP PPP2CB RAB6A CUL1 DEFB114 C3AR1 TLR2 PRSS2 FCGR3B DEFB115 ATP6V1H RPS6KA3 RASGRP2 IGHG3 MBL2 TAB3 S100B MAPK10 DNAJC3 PIGR PSMB4 PLAU NCK1 CD177 GSTP1 MAVS PLD1 IGLV7-43 MAP2K7 FUCA1 TLR8 CALML5 PSMB11 CCT2 MAP2K6 KIR2DS2 IGHV1-69 SEMG1 IGHV3-53 PYCARD CAND1 AGER HGSNAT DEFB119 TICAM1 CASP2 SUGT1 CRISP3 MAPK7 SERPINB3 CCT8 FCER1G IGLV1-47 TRIM21 COLEC11 PSMD13 TKFC KLRC2 DEFB118 ATG12 AZU1 FCGR2A CD81 IGLV2-8 HSP90B1 CLEC12A IGHV3-33 ABI1 RNF125 SARM1 PIK3CB TREM2 TLR5 FCGR1A IFNA21 PSMD9 IFNA13 RNASE3 CD33 ARMC8 CFL1 TNFAIP6 TMEM173 MUC5B C3 RNASE8 CD19 NBEAL2 CTSG TRIM25 PTAFR CAMP DEFB109B BCL2L1 PLPP5 GUSB IGLC7 PSMA8 IFNA8 IRAK2 TLR4 CD300E IST1 MAP2K3 ALOX5 MS4A3 PPP2R1A HLA-E DEFB107A LRMP TICAM2 ITPR3 GAA TRPM2 WASL AHSG VPS35L MVP REG3A ART1 VCL CFD HUWE1 TRAF2 ATP6V0B LIMK1 VRK3 APOB CFI YES1 PGLYRP2 IRAK1 POLR3GL PKM IGHV3-23 UBA3 PTPRB HSP90AA1 IGHG2 MMP25 MUC21 DEFB126 MUCL1 ITPR2 PSMB9 POLR3H DEFB125 FCN2 PDPK1 SNAP25 IGLV2-23 MUC4 SFTPA1 RELB SKP1 HMOX2 ABCA13
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Hierarchy Landscape

The following plot represents the hierarchical landscape of 'Innate Immune System'. The hierarchical tree allows to click on the pathways with children (black border) and continue the exploration. All nodes are colored by their source (click on the map for the legend) and cross-link to the original pathway page.

Sub-Pathways

About

ComPath is developed and maintained in an academic capacity by Daniel Domingo-Fernández and Charles Tapley Hoyt at the Fraunhofer SCAI Department of Bioinformatics. This web application relies on data loaded from KEGG, Reactome, and WikiPathways Restful APIs, as well as MSigDB. More information here.