Innate Immune System - Pathway Page
Name Innate Immune System
Resource Reactome
Genes PRG3 ACTB CFH SIGLEC14 POLR2L LY86 DEFB4A MYO5A YES1 PELI2 ICAM2 S100A7 IGKV2-30 RPS6KA3 HLA-E HMOX2 DHX58 PSMD10 IFI16 CAPN1 CD47 TAB2 ATP6V1F DDOST CLEC4C SIGLEC9 ATP6V0E2 GPI FABP5 LGMN PAK3 PSMD9 AGL SERPING1 BPIFB1 PRKACB MUC7 ARPC1B MUC4 IMPDH1 IGHG1 LILRA3 DEFB104A DUSP6 CEACAM3 TCIRG1 TRIM32 NOS1 DEFB125 GOLGA7 HCK PLAC8 RAB4B PIK3R2 IRAK4 IGKV1D-12 FGA DOCK2 NPC2 TLR4 HRNR MASP1 UBE2N APOB GLA TNFRSF1B IGHG2 ABI1 CD300A PGM1 GSDMD ATP6V0C UNC93B1 TLR2 MUC13 CASP4 TNFAIP3 DEFB116 PIK3CB GDI2 CD14 CYLD ARG1 MYH9 CD58 IKBKG RNASE2 ICAM3 MAPK11 STK10 CGAS ATP6V1G2 NLRC3 IGKV3-20 PRSS2 DEFB123 CD44 IGLV1-47 PROS1 TLR5 PSMA7 LAMTOR3 STOM ATG12 CEACAM6 CPN1 RAB6A CHRNB4 NOS3 S100A7A IGLV2-14 CTSS DUSP3 STBD1 SERPINB10 RHOF ALDOC TLR10 MGAM TOM1 RASGRP4 IGHG3 DEFB128 BPIFA1 TIMP2 PSMD1 HPSE UBR4 GAB2 MUC3A BCL10 PRTN3 PLD1 MAP3K1 CNN2 CXCL1 DEFB136 COLEC10 DGAT1 SPTAN1 TLR8 EEF2 TLR9 IL1B SKP1 CLEC4E FCER1G IMPDH2 PTX3 EPX MAPK10 RAP2C HEXB PSME3 PPP2R1B LYN ACLY DEFB110 PRKCSH NOS2 SERPINA1 CEP290 CFP IGKV3-11 PTPRB RAB5B PIK3C3 REG3G IGLC1 IFNB1 HGSNAT KRT1 DEFB109B POLR3A MUC17 NFKBIA CFL1 CLEC7A GAA AGA KRAS IGHV4-39 ATP6V1H NOD2 IGHV3-30 IGHV3-11 IGHV4-34 CPPED1 S100B IGLV1-40 IGHV2-5 IGLV2-23 SNAP29 BIRC2 ITGAX IFNA16 CFI RBSN DCD CD81 DEFA6 NLRC5 ACTR3 ALAD MOSPD2 RIPK2 SIRPB1 PPP2CA MAPK1 GZMM NBEAL2 POLR3F PANX1 CPNE3 DERA PSMB5 WASF3 TARM1 FCGR3A DEFB105A MAPK12 PGLYRP3 C2 C8A IGLC6 CYFIP1 IGHV3-48 ATP6V1G3 C4BPA DEFB106A PRKCD IGKV3-15 DEFB134 HBB MS4A2 MASP2 CFHR5 POLR3D FRMPD3 TLR6 ITPR3 SARM1 NCR2 DPP7 PGM2 MEF2C GRAP2 NME2 PPP3CB CNPY3 FUCA1 PDPK1 CAPZA1 NFKB1 CCT8 C5AR1 AZU1 POLR2K CCT2 HSP90B1 NLRP3 MME RAP2B PLD2 CD63 TXNDC5 CDC34 SNAP23 ARPC3 MMP25 ACTG1 PSTPIP1 PLA2G6 PSMB7 COMMD9 IGF2R TICAM2 MVP HSPA8 ATP6V0A2 PSMC3 TCN1 IGLC7 CCR6 SYNGR1 WIPF2 PSMD2 IGLV3-19 ADGRE5 TIRAP SLC27A2 ATAD3B IGKV5-2 LAT ELANE C6orf120 IGLV1-44 ARHGAP45 DTX4 LYZ PSMD12 C3AR1 PIK3R4 CARD11 ACAA1 DNM2 ADGRG3 DEFA1 RIPK1 NCKAP1L TRAPPC1 FRK PYCARD PSMB11 PTK2 SLPI COTL1 ATP6V0E1 DEFB135 NFAM1 TMEM179B SLC11A1 PSMB2 RNASE3 IQGAP2 CAB39 VCP FYN PTGES2 NF2 IGHV1-2 NKIRAS2 REG3A KIR2DS4 PPIA RAB31 GLB1 IGKV2D-30 B2M TREM2 EEF1A1 PSMD4 TSPAN14 TRAF6 ARPC2 PSMA3 RAP1B DOCK1 ITPR1 SERPINB3 PSMA4 CD46 ELMO2 DEFB115 UBE2D2 PAK2 LAMP2 BPI CD36 LCP2 ATP6V1B2 ATP7A LAIR1 LILRB3 MALT1 IFNA7 CREB1 PPP2R5D IGKV3D-20 ORM2 MAP3K7 SHC1 GSN TXN FCN3 C5AR2 IFNA21 HSP90AA1 NDUFC2 A1BG IGKV1-17 PTPN6 TRIM21 QPCT PLCG1 NIT2 PSMD7 CD300E DDX3X MEFV C1orf35 IGLV3-27 DHX9 ALDH3B1 CTSH LEAP2 STK11IP PSME2 ERP44 NOD1 CHUK PLD3 BPIFB6 NLRX1 ITGAM CLEC4A IGKV2D-28 EEA1 CHGA FCN1 CRK COLEC11 TXK WASL PRDX4 CFHR2 RAB44 DEFB113 ADAM10 PSMB1 MGST1 LTF KIR2DS2 LBP ITGAL FTH1 CRACR2A SFTPA2 MUC3B KLRD1 PKM S100A1 RAB7A SOS1 NLRP1 NFATC3 PFKL DUSP4 DNASE1L1 CFHR1 ABI2 ATP8A1 FADD PSMA5 POLR3C C1R DNM3 DEFB108A HP C7 IGLV7-43 AOC1 MNDA HK3 CDA ARSB IGHE TMEM30A SLC44A2 VAMP8 PRSS3 FLG2 IGLV3-25 TUBB4B HSP90AB1 CLU C3 NLRP4 MAPK8 RNASE7 MAPK3 DEFB130B ARSA MAP2K7 IGKV1-33 PIK3R1 CTSZ POLR3H GCA RNASE8 DEFA5 MUCL1 ARL8A ORM1 CTSV MCEMP1 PSMD11 PSMB10 NCKAP1 SIGLEC5 BCL2L1 PRDX6 SLC2A3 TMC6 ATP6V1C2 MAP3K14 CD33 CSTB DEFB107A STAT6 ATP6V1A IGKV4-1 HRAS HVCN1 CR1 C4B IGHV3-23 PSMA6 TXNIP PYGL PSEN1 FOLR3 HERC5 OSCAR APP ITGAV RAB27A BRI3 WIPF1 PSMB6 S100A9 NCF2 MMP8 WASF1 DYNC1H1 GGH LY96 FPR2 MANBA ADGRE3 SCAMP1 CAT PRKCE C8G DBNL DEFB1 PRG2 DEFB127 CD247 COMMD3 BPIFA2 ANPEP ARPC4 CPB2 PRKCQ IGLV3-21 CUL1 DEFB130A DNAJC13 TAX1BP1 CDC42 PSMC1 GPR84 IGLV2-11 CASP10 CLEC12A CD55 PLPP4 ALOX5 MBL2 PIK3CA BIN2 JUN DEFA4 OLR1 PSME4 CRISP3 PRKACA DNAJC3 RAF1 PCBP2 ADAM8 CTSL PLA2G2A PSMA2 UBB SLC2A5 UBE2L6 PPBP CREBBP RAB3D IFNA13 SIKE1 IKBKB WAS RELA PAFAH1B2 POLR3K SFTPD UBE2M MAP2K6 CPN2 IGHV4-59 LILRB2 ITGB2 FUCA2 NEU1 PIGR MIF KLRC2 VAV1 MAN2B1 ATP6V0A1 MAP3K8 ATP6AP2 GUSB CPNE1 FGG UBE2K VAPA ACTR2 MUC1 IGLV3-1 ATG7 PTPRC FCGR2A IGLV2-8 IFNA8 NFATC2 VAT1 BRK1 CLEC5A ARHGAP9 MYO1C JUP IQGAP1 HSPA1A TLR3 DEFB114 GYG1 NLRC4 IRF3 RNF216 HLA-B ARPC5 PKP1 MUC16 C4BPB PTPN11 HLA-H TRPM2 DEFB132 POLR2F CTSG ATP6V0D2 MAP2K3 MAPK7 LRMP KIR2DS5 CYB5R3 CFB DEFB129 PECAM1 BPIFB4 RNF125 MUC21 IFNA17 CYBA CRCP PTAFR ATF2 ABL1 CRP S100A12 LRG1 VPS35L RHOG KIR2DS1 HUWE1 PSMD13 IGHV3-9 ATOX1 DDX58 PSMB4 CASP2 CLEC10A ATP6V1D SRP14 CSNK2B IGHG4 IFNA6 P2RX7 CARD9 IGKV2-28 C9 RAB9B POLR1C PSMD3 DIAPH1 LAT2 TYROBP IDH1 PLEKHO2 CXCR2 LCK FOS PGLYRP4 C6 FCER1A VNN1 OTUD5 S100A8 TAB1 PGLYRP2 IGHV1-46 SERPINB12 IGKV1-5 HTN1 UBA7 PLD4 ELK1 PLPP5 UBA52 LIMK1 PSMA1 PLCG2 SERPINB6 PDXK CASP1 PSMF1 NKIRAS1 CD209 MLEC GNS ATP6V0D1 PSMB9 MAPK13 TRAF3 BIRC3 SLCO4C1 PSME1 RAB24 ATP6V1E2 TMBIM1 IGKC BTK NFKBIB CTNNB1 SEM1 SOCS1 DUSP7 P2RX1 CTSD APAF1 MUC12 ART1 C5 TRIM25 MAPK14 SAA1 LPCAT1 YPEL5 CEACAM8 AMPD3 XRCC5 NHLRC3 PSMD5 ENPP4 TLR7 KCMF1 IFIH1 CTSB ISG15 ANXA2 GNLY NFATC1 DEFB119 HTN3 NRAS RPS6KA2 VAV2 PA2G4 PSMD6 CYFIP2 ARMC8 MAP2K4 PSMB8 DSP IFNA5 GM2A CANT1 BST1 MUC5B DEFB126 DEFB121 SEMG1 SDCBP UBA3 RELB HEBP2 RAB10 HSPA1B CD300LB PPIE IRAK2 ATP6V1C1 ACPP ATP8B4 PI3 PTPRN2 PPP3CA OLFM4 SRC CLEC6A KLRK1 NCSTN POLR2H FGR PGLYRP1 UNC13D PPP2R1A ITLN1 ELMO1 ACTR10 CD177 ATP11B TANK ARPC1A FCN2 SUGT1 CALML5 PSMC4 IGKV1D-33 F2 CD180 RNASE6 GALNS BST2 SNAP25 ACTR1B MUC2 C1QA VRK3 MAPK9 C4A FTL PSMA8 ABCA13 MEF2A CAP1 CD59 COPB1 CTSA FBXW11 VAV3 PLAU DYNLL1 RPS27A HLA-C RNF135 IRF7 EP300 CMTM6 IFNA10 IGKV1-12 PADI2 DEFB112 IGHV3-53 PTPN4 ROCK1 SYK TBK1 TTR IGHV3-33 ADA2 GSTP1 AIM2 DNAJC5 DEFB133 CREG1 TREX1 PPP3R1 POLR3GL ILF2 S100P CD93 PGAM1 FCGR1A IKBKE MUC20 CCR2 PSMD8 MUC19 PDZD11 RETN DEGS1 WIPF3 DNM1 DYNC1LI1 RAP1A AP2A2 GHDC CEACAM1 IFNA14 PDAP1 MUC5AC CHI3L1 NFASC C8B ATP6V0A4 MUC6 TUBB RAB3A PSMD14 PRCP TMEM173 BAIAP2 CST3 HMGB1 DHX36 SIGLEC16 CD3G PGRMC1 NCK1 DDX41 IGHV1-69 MAPKAPK2 RAC1 AHSG LCN2 IGKV2-29 CASP9 LAMTOR1 SIRPA UBE2D1 DEFB124 FCGR3B MYD88 ATP6V0B NAPRT UBC TRAF2 DEFB103A MMP9 CAND1 NCF1 ZBP1 SIGIRR IFNA4 ANO6 C1QC NCKIPSD MAPKAPK3 ATP6V1E1 TBC1D10C TLR1 DEFB118 CXCR1 DSN1 CAMP BCL2 IGKV2D-40 POLR3G POLR3E CASP8 DYNLT1 FPR1 APEH KIR3DS1 IGKV1-16 CDK13 IGHV3-13 PTPRJ IGLV1-51 PSMC5 TAB3 VTN MYH2 CTSC SIGLEC15 RAB5C RPS6KA5 IST1 PSMC2 CTSK RAB37 PAK1 MYO10 SERPINA3 IGHV2-70 IFNA2 PIN1 DEFB108B LGALS3 POLR2E XRCC6 FAF2 SLC15A4 SERPINB1 CYSTM1 C1QB WASF2 RAB14 GLIPR1 NFKB2 QSOX1 MAP2K1 ECSIT NCF4 BPIFB2 PELI1 DEFB131A PYGB AGPAT2 DSC1 LAMP1 CALM1 KCNAB2 CYBB DOK3 RNASET2 DEFA3 TMEM63A LRRC7 EPPIN TRIM56 MAGT1 APRT CR2 CD19 RHOA UBE2V1 SVIP TNIP2 TICAM1 IGKV1-39 ATG5 ITCH HSPA6 PNP MPO AHCYL1 OSTF1 ATP11A KPNB1 GMFG AP1M1 ASAH1 POLR3B ITK IGKV1D-16 MS4A3 C1S BTRC CAPZA2 CFHR4 CLEC4D MYO9B CD68 HLA-A SURF4 ATF1 FGL2 PELI3 CD4 UBE2D3 IGKV1D-39 FGB GRB2 RIPK3 PRKACG CHIT1 IRAK1 SFTPA1 ATP6V1B1 TKFC S100A11 CKAP4 CD53 PLAUR FCAR DSG1 B4GALT1 VCL TEC CRISPLD2 CFHR3 PPP2CB RASGRP1 MUC15 ATP6V1G1 ITPR2 SELL PRKDC PSMB3 LRRFIP1 RASGRP2 TOLLIP ORMDL3 METTL7A RAB18 AGER CFD TNFAIP6 IRAK3 ALDOA MAVS PSMC6 IGHV3-7 IGLV6-57 TREM1 PSAP LTA4H RPS6KA1 GRN LAMTOR2 MRE11
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Hierarchy Landscape

The following plot represents the hierarchical landscape of 'Innate Immune System'. The hierarchical tree allows to click on the pathways with children (black border) and continue the exploration. All nodes are colored by their source (click on the map for the legend) and cross-link to the original pathway page.

Sub-Pathways

About

ComPath is developed and maintained in an academic capacity by Daniel Domingo-Fernández and Charles Tapley Hoyt at the Fraunhofer SCAI Department of Bioinformatics. This web application relies on data loaded from KEGG, Reactome, and WikiPathways Restful APIs, as well as MSigDB. More information here.