Innate Immune System - Pathway Page
Name Innate Immune System
Resource Reactome
Genes IGHG1 STAT6 CLEC4A HMGB1 CARD11 IGKV1-17 CASP2 DEFB108A AGPAT2 MNDA PYGB POLR3F IRAK1 POLR2L EP300 WASL FTL CEP290 PSMC1 LAT ASAH1 RELB CSNK2B MS4A3 IKBKG AP1M1 ATP6V0A4 TIRAP IGHG2 GM2A VAT1 HSPA8 MAP3K8 CLEC7A PAFAH1B2 PSMA2 DGAT1 SNAP25 PRKDC IMPDH2 PSMB5 IGHV1-46 PSMD11 UBE2N PRTN3 DEFB115 PGLYRP2 NKIRAS2 HCK UBE2D3 TOLLIP B2M IGHV3-30 DNM2 DEFB132 MAPK8 MAP2K3 FCER1A KIR2DS1 KCNAB2 EEF1A1 PPP2R1A DUSP6 IFNA16 ATP6V1D CD55 VAV1 ATP6V1C1 PSMB11 ALDOC ATG5 HSP90AA1 IGLV2-8 ATP6V0A2 C8B APRT LAIR1 S100A7A MASP1 EEF2 VRK3 AIM2 PRKCD IFNA2 ATP6V1H GYG1 ITPR2 HMOX2 ICAM3 NCKAP1 FGL2 PGLYRP3 MGAM TEC PSMB8 CAP1 TLR8 LAMTOR1 CXCR1 CDA CD4 ADAM8 DEFB105A DNAJC5 CFI TARM1 LAMTOR2 PELI2 SIRPB1 RAB44 ARPC4 RNASE2 NFKB1 MIF SELL DEFA6 CASP4 ORMDL3 DEFB4A RASGRP1 IGKV2-28 CTSL CHUK KPNB1 PIGR MS4A2 ATP11B CHRNB4 IRAK2 IGKV1-5 IFNA8 PECAM1 CD247 HTN3 IRAK3 CEACAM8 SPTAN1 MUCL1 MUC4 PTGES2 C3 ABI1 DEFB136 DEFB125 PROS1 MAPK14 POLR3G SEM1 PKP1 NOS3 IGF2R BST2 NFAM1 NCF1 ATP6V0B CCR6 HSPA1B C1QC PLCG2 RNASE7 LYN ADGRG3 RNASE6 DUSP7 OLFM4 C4BPB C4BPA CPN1 TTR SLC44A2 SLC2A5 MYO1C CD3G SIGLEC9 IGLV7-43 VNN1 GOLGA7 ARG1 FOLR3 HRNR PELI1 DEFA5 POLR2K ROCK1 DEFB119 CLEC4C ATP6V1E1 ATOX1 IFI16 ITCH DSG1 MYO10 SERPINA3 RAB37 CAMP TBC1D10C C2 IGHV3-9 REG3G PPP3R1 IKBKB CRISP3 LY86 PSMB2 KLRC2 IGHV1-2 C8A ICAM2 GSN PSMC5 ITGB2 NCR2 IGLV3-19 DEFA4 IKBKE RAF1 FGA S100B PSMA3 CD47 BPIFB1 PGLYRP4 JUP CD19 MAP2K4 TXK NFKBIA C1QA CTSC CD180 DNM1 CPN2 PRKCQ PSMD10 LBP GNLY FGB IGHV4-59 ADA2 PRG3 CKAP4 CFHR2 MMP9 CD300E PRKCE MUC3A MPO PPP3CB CANT1 IGHV3-11 TLR3 DEFB126 CD59 LAMTOR3 NFKBIB PPP2CA CCT8 PELI3 PTX3 RNF125 UBE2K RAC1 PIK3R1 IGLC1 DYNC1H1 CCT2 POLR2H UBR4 S100A1 AHSG POLR2E GMFG PYGL CYFIP2 PSMA1 DEFB121 SIKE1 ATP6V1G2 RETN CFB TLR4 MYO5A PSMD6 NIT2 VAV3 DEFB128 ACAA1 MUC17 TXNDC5 ITLN1 AHCYL1 ALOX5 PLA2G2A PSMB9 ALDOA APOB CD46 MAP2K6 MUC5AC HSPA1A CREG1 VPS35L C6 TICAM2 IGKV1-16 ATP8B4 MYD88 CRACR2A SVIP LRG1 DCD ATP6V1C2 ATP6V0D2 CD53 ERP44 ATP6V1E2 NFATC1 CD63 OLR1 PRCP KIR2DS5 MUC13 POLR3C TAB3 NOS1 ECSIT HLA-A PTPN6 ACTG1 YES1 LILRB3 ATP6V1B2 P2RX1 PSMB7 COLEC10 LIMK1 DPP7 BPIFA2 NCF2 HSP90B1 SYNGR1 MUC12 MUC5B STK11IP LCN2 PLD1 BPIFB6 TCIRG1 CXCL1 PDXK PDPK1 CHGA NLRP4 IGKV1-39 LCK CD68 RAB6A DEFB113 MCEMP1 ARSB TXN PRDX4 NHLRC3 NBEAL2 NCK1 RPS6KA2 TRAF6 FCAR RAP2B CEACAM1 RASGRP4 UBE2V1 ATP7A PAK3 IGLV3-21 UBE2M RPS27A CAT FPR2 BAIAP2 S100P FRMPD3 ANPEP ATG7 PLAU MMP25 CLEC12A BST1 CD33 FADD MYH9 C4A COPB1 IGLC6 ACLY MAPKAPK2 ARPC5 HBB MAPK12 COMMD9 CAPZA2 FABP5 KIR3DS1 TRIM32 DOK3 CST3 CTSD IGKV2-29 NME2 RHOF SKP1 SCAMP1 MAPK9 ISG15 PPP3CA MAN2B1 IGHV3-13 HGSNAT ITPR1 ADAM10 RAP1B DDX3X PSMC2 DEFB108B F2 CNN2 GZMM DEFB103A PSMB6 DERA BRK1 CD209 PSMD3 VAV2 NCKIPSD LCP2 OTUD5 CLEC4D UBB TRAF2 KCMF1 DEFB109B ATP6V1F TRPM2 TNFRSF1B SIGIRR PAK2 CAB39 CDK13 BCL2 PPP2R1B BPIFB2 FCN3 CAPN1 PTK2 GHDC PIK3CB ARPC2 TAX1BP1 BTK LY96 LRMP LRRFIP1 GUSB DTX4 ATP6V0E2 ITGAM RNF135 ELK1 TSPAN14 MME DEFB127 CD14 DOCK1 PLD4 CTSG IGLV1-51 MUC7 UNC93B1 S100A9 ARPC1B CXCR2 DBNL DEFB106A IGHE REG3A IFNB1 PTPRN2 FLG2 NDUFC2 NLRX1 RELA IGKV3-20 UBE2D1 DNAJC3 CTSH DEGS1 PYCARD STOM CLU COMMD3 GAA VCL MEF2C PSAP PPIE NCF4 TIMP2 STK10 LTA4H TRIM25 ATAD3B DEFB1 CARD9 ATP6V0A1 IFNA17 CYBB RAB24 TMBIM1 WIPF3 UBE2D2 HVCN1 MUC1 DEFB133 MAPK1 ACPP PGAM1 ORM1 C1S SUGT1 ARPC1A PLD3 IGKV1D-16 ITGAL RNASE8 NRAS RNASE3 PSMC6 IGKV2D-30 MUC3B LAMP2 MAPKAPK3 IL1B RAB3D IGKV2-30 RAB5C CLEC10A CUL1 PPP2CB MAP2K7 KIR2DS4 CSTB TBK1 CMTM6 IGKV1D-12 PRG2 PSMB3 EPPIN CD300LB CALML5 DEFB107A RPS6KA3 GLB1 SURF4 S100A11 SLC2A3 AP2A2 PSMD5 BPIFB4 DEFB114 PGM2 SARM1 RIPK3 LTF DEFB135 PSME2 PSEN1 MYH2 CFHR5 DSP CPPED1 NCSTN VAMP8 IGLV2-14 TRAPPC1 SERPINB6 HP UBE2L6 ARL8A HLA-H DHX9 NFATC3 UBC IGKV3D-20 PLPP4 HEXB DEFB124 TLR2 PLEKHO2 PSMA7 CFP ARMC8 KRT1 PAK1 FCGR3B IGKV1D-39 DHX36 ATP6V0C RPS6KA5 IGKV2D-40 TUBB4B CASP10 MAPK3 IGLV1-44 TXNIP CEACAM6 MUC15 PPBP CPNE3 FYN HLA-E C6orf120 MAVS PTPRC PSMA5 HRAS DYNLT1 HLA-B PTPRB DEFA3 C3AR1 CNPY3 RAB4B FCGR1A GSTP1 RNASET2 ITK SYK ZBP1 IGKV1D-33 FCGR2A ATP6V0D1 DNAJC13 UBA7 TLR9 IFNA14 ANXA2 IGKV3-11 PSMD7 RBSN FCGR3A PSMB1 CDC34 CPB2 PSMA4 MBL2 TRIM56 C1R PLAC8 CR2 CFH IGLV6-57 ATP6V1A LAT2 CRK MUC20 PIK3R2 ITGAV SERPINA1 SLC11A1 IQGAP2 IGLV1-40 PGM1 EEA1 SLC27A2 APEH DEFB118 COTL1 A1BG ADGRE3 UBA52 SERPINB3 PA2G4 MYO9B NOD2 GSDMD ACTR10 CPNE1 C4B DSC1 FUCA1 C9 DEFB116 HSP90AB1 RAB18 MUC16 IGHV4-34 POLR1C ELANE GLIPR1 PANX1 TREX1 MUC21 IGHG4 HTN1 LRRC7 TLR1 FBXW11 IGLV3-25 FCN1 TMEM63A RAP2C PRKACA TNFAIP3 NF2 LILRB2 DSN1 STBD1 KLRK1 TYROBP PLAUR PFKL C7 MAP3K1 ATG12 CYLD GPI MVP CEACAM3 TAB1 DEFB104A QPCT RIPK2 P2RX7 DHX58 TLR7 LILRA3 PTAFR CFL1 HK3 CDC42 SHC1 IGLV2-11 ACTR3 IST1 YPEL5 SEMG1 PLA2G6 EPX MAGT1 CYBA ELMO1 PSMD9 COLEC11 MRE11 MLEC IGHV1-69 PRKACB CR1 PSTPIP1 CTSZ RPS6KA1 SLPI POLR2F HEBP2 CASP9 PPIA WIPF2 PDZD11 FOS KRAS RAB3A ATP6V1G3 C1QB LGALS3 ABCA13 AGER MAP3K7 DEFB134 TLR5 PI3 PIK3R4 APP DEFB112 FPR1 VAPA TMEM179B OSTF1 TOM1 MOSPD2 TREM2 RAB9B CFHR4 IFNA5 RHOG VCP PSME4 MAPK10 CD93 ELMO2 PGRMC1 IGKV5-2 IGHV3-53 CTSB IGKV4-1 C5 DOCK2 UNC13D IFNA21 IGKV1-12 GGH SRC DEFB110 GCA CAND1 CHIT1 DEFA1 GNS CAPZA1 IGLV2-23 NLRC4 IDH1 SERPING1 CRCP BCL10 CD44 SIGLEC15 SOCS1 GRB2 MEFV WASF2 IGKV1-33 POLR3K MUC19 PDAP1 ARPC3 LYZ MAPK11 NLRP1 PKM FRK SIGLEC16 ATP6AP2 GALNS RAP1A TAB2 SAA1 RAB7A HPSE ATP6V1G1 ATP6V1B1 CTSK PCBP2 MAP2K1 HSPA6 CTNNB1 CYSTM1 IGHV2-5 PSMB10 IGHG3 ARHGAP45 ITGAX PGLYRP1 CTSV MUC2 KLRD1 IRAK4 LAMP1 RNF216 MALT1 CTSS PPP2R5D SLC15A4 BPI KIR2DS2 ALDH3B1 ALAD FCER1G PRDX6 CASP1 CD300A NFATC2 ABL1 MAPK7 CRP PLD2 PSMF1 PSMD4 CALM1 DEFB131A TNFAIP6 GRAP2 MAPK13 IMPDH1 SRP14 APAF1 CGAS NPC2 XRCC6 ADGRE5 AOC1 IFNA13 TMEM173 CYFIP1 POLR3E IGLV3-27 S100A12 BIRC2 ACTR1B FGR BRI3 MEF2A RIPK1 CTSA DNM3 IGHV3-48 PSME1 ACTR2 POLR3D RAB10 CLEC6A NLRC3 OSCAR NFKB2 PNP AGL MASP2 ORM2 BPIFA1 BIN2 AMPD3 ITPR3 NOS2 ATP6V0E1 NLRC5 TMC6 PRSS3 HUWE1 TNIP2 POLR3H C5AR1 DDX41 TUBB S100A8 TLR10 IQGAP1 IGLC7 NOD1 ATF2 POLR3A TREM1 WIPF1 TRAF3 CYB5R3 IFNA6 MAP3K14 ABI2 LEAP2 PIK3C3 CREBBP IGHV2-70 FCN2 ARSA CASP8 SFTPA1 CD177 IRF7 MUC6 CCR2 C8G GLA SFTPD IFIH1 ATP11A BCL2L1 CLEC4E LGMN METTL7A HLA-C PSMA8 ACTB PTPRJ NFASC ART1 DDX58 DDOST PSMD1 CRISPLD2 PSMD13 PSMD2 SERPINB1 JUN PSMC3 SNAP29 GRN IGHV3-23 ATP8A1 IFNA4 PLPP5 IGLV3-1 IFNA7 C1orf35 CHI3L1 TRIM21 SLCO4C1 IGHV4-39 C5AR2 CD58 DUSP3 RAB14 TLR6 PRKACG DUSP4 CLEC5A PLCG1 GAB2 QSOX1 IGKC PRSS2 FTH1 DEFB130A CD36 DNASE1L1 DYNLL1 DEFB130B IRF3 ANO6 CD81 LPCAT1 ATF1 TANK DYNC1LI1 CFD MGST1 POLR3B VTN NLRP3 GPR84 PIN1 PIK3CA TKFC IGLV1-47 IGHV3-7 SOS1 CREB1 DIAPH1 WASF3 DEFB129 PSMC4 PADI2 NAPRT B4GALT1 SIGLEC14 IFNA10 HERC5 NKIRAS1 IGKV3-15 S100A7 SDCBP SERPINB12 RHOA RAB5B FUCA2 ENPP4 BIRC3 TMEM30A MMP8 NEU1 BTRC PSMB4 PRKCSH PSMA6 XRCC5 TCN1 AGA PTPN4 RAB27A UBA3 SNAP23 MANBA SIGLEC5 AZU1 SERPINB10 POLR3GL IGHV3-33 PSMD8 SFTPA2 CFHR3 FAF2 TICAM1 PSME3 SIRPA GDI2 DEFB123 PSMD12 PSMD14 RAB31 RASGRP2 IGKV2D-28 WASF1 FGG CFHR1 NCKAP1L ILF2 WAS PTPN11 ARHGAP9
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Hierarchy Landscape

The following plot represents the hierarchical landscape of 'Innate Immune System'. The hierarchical tree allows to click on the pathways with children (black border) and continue the exploration. All nodes are colored by their source (click on the map for the legend) and cross-link to the original pathway page.

Sub-Pathways

About

ComPath is developed and maintained in an academic capacity by Daniel Domingo-Fernández and Charles Tapley Hoyt at the Fraunhofer SCAI Department of Bioinformatics. This web application relies on data loaded from KEGG, Reactome, and WikiPathways Restful APIs, as well as MSigDB. More information here.