Innate Immune System - Pathway Page
Name Innate Immune System
Resource Reactome
Genes GSN PTPRJ CRISPLD2 CYB5R3 PTGES2 DDX41 DEFB125 POLR3F POLR2H CD53 PPP3CA CD93 DEFB135 ITLN1 C4BPB MYO1C GPR84 CD63 IGHG3 IGKV1D-16 SFTPA2 HSPA1A FCN2 DEFB116 IGHV3-33 ATP6V1E2 CTSC DEFB133 MUCL1 APP LTF CEP290 STK10 C3AR1 CFHR4 RAB18 MMP25 UBE2D1 DYNLT1 ZBP1 HEBP2 POLR3H PSMB9 IGLV6-57 IGHV3-48 UBE2L6 IFNA5 NCKAP1L SUGT1 DGAT1 SLCO4C1 TYROBP ATP6V0D2 NCKIPSD PANX1 TUBB LGALS3 DEFB115 RASGRP4 POLR3D RPS27A IFNA16 WASF2 TLR10 ARPC2 PFKL SCAMP1 CEACAM6 LRG1 NPC2 PKM CD59 MYD88 ACPP SAA1 AGA TLR8 ATP6V1G3 TRIM21 CHUK MASP1 KLRK1 SERPINB6 MAN2B1 MLEC KIR2DS5 ELMO1 CPNE3 MAPK10 IGKV5-2 ARPC1A FADD CD4 XRCC6 HK3 PLAC8 ADA2 RNASE3 LAIR1 BPIFB6 PSMD9 CXCL1 RAF1 NME2 GRAP2 ATP6V1B1 RHOF PRTN3 LILRA3 IGLC1 PSMD1 EEA1 FLG2 MAP3K7 IL1B TLR1 PRG2 SEM1 MALT1 ATP6V0E1 UBA7 ACTR3 CFH IGLV3-19 CD19 PGM1 SOCS1 DEFB105A TMEM179B MUC6 SIKE1 IFNA17 PLPP5 AGPAT2 S100A8 CASP10 FCAR PLPP4 MNDA C1QB ABL1 CD300LB LYN CTSL RAP2C MAVS GSDMD MGAM PSME1 FGA DEFB121 CASP1 IGKV3D-20 UBE2D2 DDX58 PSMB11 PIK3R1 KIR2DS1 CXCR2 CSNK2B NCSTN ALDOA PSMB10 ATP6V1A CGAS ATP6V1H C9 LAMP2 CARD9 SPTAN1 CD14 CYLD CAND1 GMFG PSMC4 SEMG1 SARM1 PPP3R1 IFNA4 STK11IP IGKV1D-33 EEF1A1 ILF2 C8G YPEL5 CLEC4A S100A7A VTN UBE2K LRMP DPP7 SELL PIK3CB MUC3B PLA2G6 DEFA3 TLR2 ARHGAP45 PLD2 WIPF2 NFKB2 PTK2 SRC ANPEP MAPK14 PSMB4 LCN2 SURF4 PTX3 DEFB107A S100B ARPC1B PDXK CYFIP2 PLAUR MAPKAPK2 RNASE7 IGHV2-70 FRMPD3 ATP6V1B2 C7 ITGAL POLR3G P2RX1 ARL8A NLRC4 GNLY BAIAP2 PSMC3 CHI3L1 MUC15 CST3 VAPA CCT2 PLCG2 FAF2 HBB WIPF1 CLEC6A CD300A PSMB7 PAK1 SFTPD PSAP CD36 AOC1 ITPR2 PELI1 CD247 CRISP3 PSMB5 IFNA13 DOCK2 RBSN TXNIP PDZD11 HSP90AB1 ABCA13 C3 NOS3 IGLV1-51 PSME3 CYSTM1 TXN EPX RAB24 KRAS TNFAIP6 ATP8A1 PRKCQ DEFB130A ACTR1B MUC13 CEACAM8 PSMB2 STBD1 CREB1 ANO6 C1QC ORM2 CLEC12A MAPK8 LY96 POLR2L BCL2L1 TTR DNAJC3 CTSZ RAB4B MAPK3 TLR5 TMEM30A RAB14 PSMB3 ROCK1 TXK ITGAM ARPC3 GRN MUC12 NFKBIB GSTP1 IRAK4 PSMA5 HRNR ARMC8 GOLGA7 UBE2V1 CDC34 TREM2 TCN1 PCBP2 GLA ITGAX PGLYRP4 VCP RETN PRSS3 RAB37 NOD1 ADGRE5 IGKV2D-28 PADI2 CCR6 RNASET2 FTL IGHV1-2 ITK RNASE2 B4GALT1 IGKV2D-40 ITPR3 IGF2R GLIPR1 HTN1 IMPDH2 CD177 NFATC2 RPS6KA1 SNAP23 IFNA2 PRKACA TBK1 MAP2K1 MCEMP1 TAB2 IGKV4-1 CRK ELMO2 APAF1 C1QA HUWE1 AMPD3 PPP2R5D ATOX1 ECSIT DSC1 ATP6V0A2 TEC TREM1 RAB27A CPB2 PDAP1 IDH1 BST2 CAPN1 SLC27A2 ACTR10 NCF4 SYK MAP3K14 ADGRG3 NDUFC2 MYO9B PRKCSH CYBA CD44 PSMD5 QSOX1 PDPK1 CTSV IGKV2-29 KCNAB2 DEFA4 AGL VRK3 MANBA IFNA10 WIPF3 LGMN CFHR3 DUSP4 ADAM10 CAMP PRCP LAMP1 CTSB CD81 B2M FCER1A AP2A2 UNC93B1 APRT RAP1B NFAM1 IFIH1 DEFB128 IGHV3-13 BIN2 PIK3C3 TMEM63A VPS35L IGHV4-39 IGHV3-9 SFTPA1 SIGLEC15 MAPK11 GAB2 IGKV2D-30 FBXW11 DEFB127 STOM CAB39 NF2 BTK SERPINB1 IFNA21 PNP IRF3 MYH9 ATP6V1E1 FCGR2A MAPK1 RIPK1 PTPRB SYNGR1 PIN1 MAPK13 POLR2K CFB CAT DDOST TMC6 BCL2 APOB MAP3K1 DEFB110 PELI3 DEFA5 CTSA RAP2B C5AR1 CLEC4D JUN RPS6KA3 P2RX7 PSMB1 MAPK9 SIRPA C6orf120 EEF2 GZMM HRAS SRP14 DEFB118 NFATC1 METTL7A PPIE MUC16 TAX1BP1 CKAP4 ATG5 IQGAP1 LAMTOR2 S100A1 PSMD4 XRCC5 FTH1 RNF216 TCIRG1 IRF7 PGAM1 PROS1 KIR2DS4 ICAM2 CHIT1 PYGB FYN OLR1 RPS6KA2 ARG1 PRG3 MAP2K7 TIMP2 F2 KPNB1 IGHV3-23 PLCG1 NLRP3 NCF1 PPBP NOS2 POLR3E S100A12 FCGR3A IGHV3-30 PKP1 CLEC4E NFKBIA NLRX1 LYZ S100A11 DEFB132 PSMD12 FCGR1A RAB7A PSMD14 AHCYL1 DEFB123 SHC1 MS4A2 ARSB ALOX5 ACLY DEFB106A CTSS CEACAM3 TRAPPC1 NFASC NCKAP1 RELA PIK3R4 CD180 IGHE PPIA ATP11A IGKV1-39 LAMTOR1 ORM1 BPIFA1 SOS1 MYO5A FABP5 TOLLIP COMMD3 ARSA IGHV1-46 SIGLEC9 PRKACB MAP3K8 SERPINA1 MUC21 PSMA7 MPO BPIFB1 PPP3CB ATP6V1F ALDH3B1 MMP8 IGLV1-40 TRAF2 RAB3A PSMA1 DUSP3 IGKV1-16 IKBKE NAPRT CALM1 SLC11A1 AGER IGKV1D-12 DYNC1LI1 ERP44 PPP2CB FOS ARHGAP9 RASGRP2 BIRC2 TMEM173 UBE2D3 PYGL BPIFB2 GALNS PYCARD CD300E NLRP4 PIGR HLA-B ISG15 TOM1 RAB44 MAGT1 PELI2 MAP2K6 ATP8B4 CDC42 MUC20 DOK3 LBP LRRFIP1 TMBIM1 ATAD3B SERPINB3 POLR2E HVCN1 TNIP2 WASF3 CFI CTSD ANXA2 CD46 VNN1 CYFIP1 IQGAP2 BRK1 IGLV3-21 CDK13 FGB CCR2 UBB PSMD10 PSMD3 NBEAL2 TREX1 PSMF1 TLR7 RELB JUP RNASE8 MUC4 IRAK2 LCP2 BTRC CLEC10A IFNA8 PLD4 RNF135 MRE11 CTSH PGLYRP2 ABI1 SNAP25 PSMD8 PIK3R2 DEGS1 PSMD6 GPI WAS IGKV1-17 PGM2 PLEKHO2 DEFB108A DEFB136 IGHV3-11 PPP2CA PI3 NFKB1 IGHV3-53 GM2A POLR3C IGHG2 RASGRP1 C4A ORMDL3 GAA TANK CTSK CANT1 PSME2 CTNNB1 PTAFR DEFB108B SERPING1 BST1 PTPN4 IGLV7-43 KLRD1 ARPC4 TRIM25 LILRB3 ATG7 IGKV1D-39 SDCBP NLRC3 CPNE1 PSMD13 EPPIN FPR2 DSP PAFAH1B2 FGG ADGRE3 CD58 TLR3 PSMA8 IRAK1 NEU1 PRDX6 IGLV3-27 PSMD11 LAT2 SVIP HEXB COMMD9 BIRC3 PRSS2 HGSNAT PSEN1 CTSG VAV3 HLA-H CRP RIPK3 ACTR2 TRIM56 IGLC6 STAT6 UBA3 IGLV2-11 RAP1A DOCK1 SLC2A5 PRKCD PECAM1 GRB2 PSTPIP1 BRI3 ATP6AP2 SKP1 MASP2 ATP6V1D C1orf35 DEFB4A GUSB FUCA1 CLEC7A MVP IGHV2-5 SIGLEC14 LPCAT1 ELK1 ITCH CHGA HSPA1B C8A GDI2 NFATC3 IFNB1 CD68 DHX36 MYO10 HCK HMGB1 ATP6V1G2 CFL1 CASP8 MYH2 HP LRRC7 PSMB8 PSMD2 RAB9B PPP2R1B BCL10 NCR2 DEFB114 IGKC MOSPD2 ATF2 LCK ACAA1 ATG12 DERA IGLV3-25 HSPA6 SLC2A3 DNM1 PRKCE TLR4 ARPC5 PLA2G2A TLR9 ACTB CCT8 PGLYRP3 RAC1 TARM1 FGR HLA-E DEFB104A SIGLEC16 AIM2 CD55 TXNDC5 AP1M1 TIRAP CREG1 CD209 EP300 ENPP4 COLEC10 NCK1 MUC3A ITPR1 MUC17 TRIM32 PRKDC TKFC CNPY3 DYNLL1 FUCA2 IKBKB PRDX4 IGKV3-15 CARD11 PSMA3 SLPI OSTF1 UBE2N FOLR3 MAP2K4 PSMA4 GYG1 NOS1 SERPINB12 ACTG1 CAPZA2 CLU IST1 HLA-A A1BG CYBB HMOX2 DNAJC13 CREBBP ART1 LY86 IKBKG CASP2 PAK3 ALDOC TLR6 MUC5AC RAB31 RNASE6 MAPKAPK3 MIF CR2 SERPINB10 IFI16 REG3G SIRPB1 FGL2 MAPK7 ATP7A DEFB126 IGHV4-34 ITGB2 ITGAV PTPRN2 RPS6KA5 IGLC7 HSP90AA1 TAB1 PRKACG S100A9 C1R FPR1 ATP6V0A4 SERPINA3 OLFM4 DTX4 DEFA6 NRAS DUSP6 HSP90B1 ATP6V0A1 TICAM1 RNF125 MUC1 DEFA1 TICAM2 S100A7 DEFB109B ATP6V0C IGHV3-7 KIR3DS1 CALML5 GGH TNFAIP3 FCN3 YES1 VAV2 FCGR3B MAPK12 PSMA6 COTL1 IFNA14 PPP2R1A DHX58 UBA52 HPSE POLR3A RAB3D TUBB4B GLB1 MEFV PA2G4 RHOA CFHR2 DDX3X PTPRC PSME4 MAP2K3 IGLV3-1 CR1 FRK AZU1 TBC1D10C TAB3 SIGIRR PSMC6 WASF1 IFNA7 SNAP29 BPI POLR3K GCA CRACR2A DEFB1 SLC44A2 NIT2 CDA CFHR5 HTN3 CNN2 IGKV3-11 IGLV2-14 IGKV3-20 IGHV1-69 DUSP7 IGLV2-23 CPN2 NLRP1 RAB10 VAMP8 ATP11B CMTM6 DEFB112 BPIFA2 PSMC5 CFP CLEC5A IGKV2-30 DNAJC5 TRAF3 BPIFB4 NKIRAS1 IGHG4 VCL OTUD5 UBE2M KIR2DS2 C6 DBNL ATP6V1C2 RAB6A GNS PGRMC1 C1S MBL2 LAT DEFB131A MUC2 MEF2C CD47 POLR3GL WASL KCMF1 LILRB2 DNM2 COLEC11 MEF2A UNC13D HERC5 VAV1 CPPED1 CFD SIGLEC5 CD33 PLD1 PLD3 RAB5C IGKV2-28 IGKV1-33 CD3G C5AR2 PGLYRP1 ATP6V1G1 NOD2 PSMA2 PTPN11 CAP1 TRAF6 AHSG PIK3CA TSPAN14 TRPM2 CPN1 DSN1 FCER1G PSMC2 DEFB103A POLR1C LIMK1 IGKV1-5 ATP6V0B DEFB134 PTPN6 NCF2 DYNC1H1 DIAPH1 OSCAR CFHR1 IMPDH1 POLR2F CEACAM1 RIPK2 ELANE MUC5B IFNA6 IGLV2-8 MUC7 QPCT PLAU KLRC2 UBC C4BPA NLRC5 ATF1 LEAP2 IRAK3 CRCP DNASE1L1 S100P HLA-C MMP9 C4B PAK2 CSTB DCD DEFB129 SLC15A4 PSMB6 FCN1 C8B DEFB124 APEH CXCR1 POLR3B PSMC1 PSMD7 ABI2 MME MUC19 CHRNB4 LTA4H UBR4 CUL1 GHDC C2 NHLRC3 IGHG1 NKIRAS2 KRT1 ICAM3 IGHV4-59 ATP6V1C1 IGKV1-12 VAT1 ASAH1 CAPZA1 DEFB113 DSG1 ATP6V0E2 RHOG TNFRSF1B COPB1 ATP6V0D1 DEFB119 DHX9 MGST1 DNM3 LAMTOR3 CASP4 RAB5B CLEC4C CASP9 C5 HSPA8 ALAD DEFB130B MS4A3 REG3A IGLV1-47 ADAM8 IGLV1-44
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Hierarchy Landscape

The following plot represents the hierarchical landscape of 'Innate Immune System'. The hierarchical tree allows to click on the pathways with children (black border) and continue the exploration. All nodes are colored by their source (click on the map for the legend) and cross-link to the original pathway page.

Sub-Pathways

About

ComPath is developed and maintained in an academic capacity by Daniel Domingo-Fernández and Charles Tapley Hoyt at the Fraunhofer SCAI Department of Bioinformatics. This web application relies on data loaded from KEGG, Reactome, and WikiPathways Restful APIs, as well as MSigDB. More information here.