Innate Immune System - Pathway Page
Name Innate Immune System
Resource Reactome
Genes MMP9 ARPC2 C7 CFHR4 DEFA5 PRKCE IGLV3-1 ACTR2 PPP3CA RAC1 RAB5C C6 PGAM1 MUC6 ATP8A1 DPP7 GDI2 NCKIPSD MGST1 CCR6 XRCC6 TMBIM1 HSPA1B PLPP5 HSPA1A PSMC2 TAX1BP1 CHGA FABP5 DEFB109B PIK3R1 ALOX5 ATP6AP2 KRAS IGF2R DEFB1 PLA2G2A CCR2 SLC2A3 IFNA7 MCEMP1 TCIRG1 PLA2G6 IQGAP2 TREX1 MEF2C CCT2 NLRC3 WASF3 CR1 STK10 CARD11 B4GALT1 MUC7 RPS6KA3 CKAP4 CPB2 NFATC2 HEBP2 LAMTOR2 CD19 FTH1 ABL1 MLEC HEXB ARPC1A UBB RHOA TRIM32 TAB3 PAFAH1B2 IGLV1-44 SNAP23 CYFIP1 MUC16 DNAJC3 F2 ATP6V1G1 IGLC6 PSMA6 OSTF1 NFKB1 DEFB113 DEFB114 DNAJC5 YPEL5 PGRMC1 CD3G RAB14 MAP2K1 FLG2 CD33 CTNNB1 POLR3K KIR2DS2 ECSIT RAP1A GPR84 CRISPLD2 CGAS PDAP1 POLR2L TLR6 P2RX1 ATP8B4 TXNIP C4A IGKV1-12 POLR3E CASP2 S100A1 NRAS IGKV2-29 TBK1 CXCR1 SLC44A2 FCN2 FPR2 CXCR2 ICAM3 MS4A2 PGLYRP2 MAP2K3 MGAM ITPR3 TAB2 NOS3 BAIAP2 TCN1 S100A11 CD247 NIT2 MRE11 UBR4 RAP2C CFHR1 IGHG2 CD4 RBSN PSTPIP1 TLR8 CD53 PSME2 TRAF2 MAPK14 NME2 OLFM4 IRF7 DEFB126 PSMD9 NFKB2 CRISP3 MVP FCGR1A DEFA4 CRCP ADGRE3 IGHV3-23 MUC15 SKP1 IRAK2 HSP90B1 FBXW11 CTSZ NLRC5 FOLR3 PSME3 TLR1 BRK1 PGLYRP3 CALML5 RNASET2 PRKDC POLR3GL SVIP POLR3F PPBP TMEM173 RAB24 IGKV2D-28 SNAP29 BCL2L1 GNS BCL10 IGHV1-2 CTSL DYNLT1 COLEC10 CLU TUBB4B ATP6V1E2 PSMD5 ATF2 CD177 PPIA DSG1 KIR3DS1 ATP6V1B1 DEFB127 ACPP RAB27A CFHR3 IGKV2D-40 ART1 TRAF3 GPI NCF1 GALNS ATP6V1D COMMD9 MIF PSEN1 TSPAN14 CDC34 RAB7A HSP90AA1 ABI2 TRAF6 MYH2 IGKV1D-16 APP DSC1 XRCC5 PLPP4 TXN DEFB103A COMMD3 IGHV3-53 PTPRB ADAM8 OLR1 PGLYRP1 ADAM10 SLC15A4 MMP8 MAPK7 ATP6V1G2 KCMF1 SLC11A1 PTPN6 CALM1 PLAC8 MUC4 KLRC2 PAK1 SERPINB1 MANBA TYROBP PANX1 DEFB129 LAIR1 MOSPD2 IFNA6 IFNA2 PPP3R1 LAMP1 PSMD7 C1QC GOLGA7 SFTPA2 UBE2D2 IGHV3-33 TMEM30A AHSG PRKCD CAND1 PTPRJ PKP1 DEFA3 ATP6V0B DDX3X NOD2 LPCAT1 NLRP1 AP1M1 PGM1 PRCP PPP2R1B RAB9B ELK1 BIRC3 CD300E CLEC6A UBE2M CASP1 DYNLL1 FCN1 GRN SRP14 IFNA13 ATP6V1A CHUK HLA-A NCSTN LRRFIP1 PSMD13 UBE2V1 MUC17 CANT1 MUC21 PSMB11 MUC19 ALDOA CAPZA1 AGA DEFB124 IGLV1-51 VAMP8 GCA IGHV3-9 IGKV3D-20 CD59 ITGB2 WIPF2 AGER IGLV2-11 SOS1 DDX58 SIGLEC9 AIM2 RPS6KA2 ANPEP LRG1 PSMB3 KPNB1 DDX41 TIMP2 RPS27A IFNA21 BST2 LGMN HLA-H CR2 ATG7 PSMB1 PRKACG LCK IKBKB RELA B2M IGKV3-20 RETN DEFB136 ORMDL3 CTSS IGKV3-11 C8G SEM1 TRIM56 IGKV5-2 ASAH1 MAVS TRIM21 MAPKAPK2 NCKAP1 QPCT CFHR2 CXCL1 MASP1 VAT1 CD55 PTAFR DUSP6 RNASE2 GSTP1 CD300LB NCF2 PTPN11 LILRA3 CFH UBE2N FGR SLC2A5 HMOX2 YES1 HCK CNPY3 C1QA COLEC11 SOCS1 GGH PECAM1 POLR3H CTSC PDPK1 NLRC4 FAF2 FUCA2 LY86 ARG1 HSP90AB1 FCGR3A PLCG1 IFNA17 GLB1 C9 VRK3 ELMO1 PSMB6 IFNB1 S100A7A IMPDH1 NHLRC3 PRDX6 EEF1A1 MUC2 CFB HLA-E NCK1 MAPK3 AP2A2 CLEC4E GHDC UNC93B1 PSMA8 PSME1 ZBP1 RAF1 POLR3G LTA4H BPIFB6 ATP6V1H ARSA METTL7A ATP6V0E1 LRRC7 IL1B PROS1 BTRC FCGR3B HLA-C RPS6KA1 PSMD8 VAV3 MAP3K7 RAB18 RAB10 TBC1D10C IGKC NKIRAS2 LBP PSMF1 CREBBP PI3 ATAD3B CD63 TLR5 CD58 ADGRE5 IGLV7-43 CCT8 ARSB PIGR IST1 PPP2R5D DOK3 CYLD LAMTOR3 MAP3K14 CDK13 C1orf35 BIRC2 PSMD2 PTGES2 DEFA6 DEFB130A DEFB131A DUSP7 DEFB110 IGKV1D-33 DEFB106A NFKBIB LTF IGHG1 JUN PNP DEFB105A MME SFTPA1 CFL1 CEACAM3 PDZD11 MUC5B CTSA CLEC4C PSME4 PDXK PSMD12 LAMTOR1 MAPK9 UBA7 PCBP2 TLR3 MAGT1 C1QB SPTAN1 MAPK1 ABI1 ARPC5 DCD UBE2D1 RAB6A NFAM1 PSMB4 MNDA PIK3C3 CYBA IGLV3-21 AHCYL1 PTPRN2 IGLV2-23 CRP FGG FYN BPIFB2 PSMA3 ITGAX PSMB8 POLR1C TMEM63A UBA52 HUWE1 CYB5R3 ACTR3 IGLV3-25 TNIP2 NOS1 NFATC3 TRPM2 TXNDC5 C1R PIK3R4 POLR3D IGHE BRI3 MAN2B1 PSMD6 CLEC4D DEFB134 MBL2 IFIH1 IGKV2-28 DNAJC13 PSMB2 FTL POLR3B PRTN3 RIPK2 CAPZA2 VNN1 IGKV1-17 SYNGR1 IGLV2-8 BIN2 SERPINA3 PRKACA CTSH CD68 PIK3R2 CUL1 CTSG DEFB4A DNM2 NLRP3 ACTR1B APEH DEFB133 ATP6V0D1 MYO5A RAB44 BST1 IFNA10 CAPN1 IRAK1 C3AR1 NBEAL2 CSNK2B ELMO2 C6orf120 MUC12 NCR2 IGKV4-1 HSPA8 LILRB3 IGHV1-69 GLA MAP2K4 CD180 LYZ LEAP2 DEFB107A GSDMD ADGRG3 PSMD3 ANXA2 DOCK1 IGKV1-39 IGHV3-48 MAP3K1 IGLC7 ATP7A MYO1C PAK2 HTN1 IGHG3 PSMB9 LAT NDUFC2 DIAPH1 SIGLEC14 LCP2 ISG15 APRT PFKL DEFB116 TREM1 TICAM2 S100A12 CHRNB4 TLR4 CD209 PYCARD TTR PSMC5 SIGLEC16 CASP4 TOLLIP RAB4B CD93 PSMA7 SIGLEC5 GRAP2 PTPN4 CPPED1 MYD88 ARPC4 IGKV1-5 IGKV1-16 CDA GM2A LCN2 SDCBP PSMB5 PSMA2 CAMP IFNA8 HK3 CRACR2A IRF3 IGLV1-47 GSN ATP6V0E2 DOCK2 TRIM25 SFTPD ATP6V0D2 CASP9 DHX58 TLR10 RIPK1 SLC27A2 IRAK3 ENPP4 DEFB108A MAPK10 PLCG2 ATP6V1B2 CHIT1 SARM1 CD300A KIR2DS4 NLRX1 MYO9B ATP6V1G3 PSAP SIRPB1 EPPIN VAV1 SCAMP1 DEFB130B SIGIRR CREG1 PIK3CA MAP3K8 ADA2 IGKV1D-39 RPS6KA5 REG3A EEA1 TMEM179B OTUD5 ATF1 QSOX1 PRKCQ ACAA1 TMC6 CYSTM1 DEFB121 MALT1 PLD2 ARPC3 DEFB125 SRC IGKV2D-30 IGLV1-40 FRK PLEKHO2 C5AR2 CAT MS4A3 POLR2E PLD1 SERPINA1 DHX9 CNN2 ANO6 DUSP3 PSMC4 BPIFA2 GAA CEP290 CTSK BPIFB1 EP300 ATP6V1F MAPK8 IFNA5 STK11IP PRG2 ARHGAP45 PLD4 CYBB C4BPB UBE2D3 BPI ABCA13 DSN1 CHI3L1 CAB39 PLAU CD36 LGALS3 BCL2 CTSV CLEC12A CPNE1 LILRB2 CREB1 KIR2DS1 NCKAP1L TKFC NF2 ARL8A SEMG1 DYNC1LI1 MYH9 TNFRSF1B CFP IGKV2-30 WAS STBD1 RNASE6 EEF2 HP CEACAM8 RIPK3 PSMD11 FPR1 DNASE1L1 MEFV GYG1 KLRD1 GAB2 RAB3D TARM1 C8A ATP6V1E1 CST3 S100A8 ARPC1B MUC1 ORM2 SHC1 MUC3A VTN SELL JUP PPIE CD44 PKM MAP2K7 DEFA1 ICAM2 LY96 GLIPR1 ORM1 CAP1 DEGS1 PSMB10 LYN C4BPA IGLV3-19 KLRK1 GMFG UBA3 ACTB LIMK1 ACLY IQGAP1 C8B DNM3 PTPRC PPP2R1A DUSP4 FGL2 ATP6V0A2 PSMC3 PSMD10 AGPAT2 ILF2 IFNA16 DEFB135 C5AR1 MUCL1 PGLYRP4 ATP6V0A4 CASP8 DEFB119 RELB MUC3B DEFB118 BPIFB4 RHOG TOM1 STAT6 SERPINB10 ATG5 ITGAV IGLV6-57 DSP PSMA4 FCN3 PAK3 CLEC5A DEFB132 COPB1 FCER1G IGHV2-5 MASP2 TAB1 SERPINB6 SURF4 CEACAM1 S100B PSMD14 ACTR10 SIGLEC15 RAB31 PRSS3 SUGT1 CFHR5 VCP ELANE IGHV4-34 PA2G4 NFKBIA TXK RNF125 DBNL MUC5AC AMPD3 IRAK4 S100A7 PRKCSH RAB3A C4B DEFB128 IGKV1D-12 DEFB112 KCNAB2 UNC13D CD47 GUSB A1BG ATP6V1C2 CMTM6 CASP10 FCER1A GRB2 DNM1 IGHV4-59 IGHV2-70 TUBB PLAUR MAPK13 CTSD TEC RASGRP2 ARMC8 TANK RASGRP4 RNASE3 IGLC1 PADI2 WASL LAMP2 LAT2 CD14 PIK3CB HRNR TREM2 FUCA1 GNLY C3 PTX3 IGKV3-15 RNASE7 IMPDH2 FOS EPX DEFB108B ITPR1 PSMD1 ALDH3B1 IGHG4 RASGRP1 TLR9 SLPI MUC20 DEFB123 HRAS PSMC1 TNFAIP3 NCF4 PSMC6 MEF2A IGKV1-33 PRSS2 MAPK12 GZMM CDC42 ITLN1 CFI RAP2B VCL RAB37 MAPK11 IKBKG MAP2K6 HMGB1 AGL CARD9 PSMA1 UBE2L6 IFNA4 PPP2CA ACTG1 CTSB HVCN1 C1S RHOF MUC13 VPS35L CFD POLR3C CPNE3 IGLV2-14 SLCO4C1 DEFB104A DYNC1H1 CEACAM6 FADD ARHGAP9 ATP11B OSCAR UBC TIRAP SIRPA ALAD PTK2 NEU1 IGHV4-39 PELI1 POLR2H IGHV3-30 APAF1 PGM2 NLRP4 WASF1 ERP44 FCAR ATP6V1C1 HGSNAT CPN2 SERPING1 IGHV1-46 ITK SNAP25 AOC1 DEFB115 ITPR2 DGAT1 REG3G MMP25 ITGAL KIR2DS5 KRT1 DERA HBB SERPINB12 PRG3 POLR3A STOM AZU1 PSMD4 TNFAIP6 NKIRAS1 MPO ITGAM ATOX1 ATP11A RNASE8 HTN3 CPN1 IFNA14 DHX36 VAV2 NOD1 NOS2 PRKACB RAB5B WIPF3 PPP2CB RNF135 ATP6V0A1 PPP3CB CYFIP2 S100A9 WASF2 POLR2F FRMPD3 UBE2K BPIFA1 NAPRT FGB TLR7 SYK IFI16 IDH1 ALDOC ROCK1 CLEC4A ITCH ATG12 DDOST PYGL TLR2 PYGB SAA1 POLR2K C5 IKBKE HPSE FCGR2A FGA RNF216 IGLV3-27 CSTB DTX4 RAP1B CD81 NFASC WIPF1 COTL1 BTK TRAPPC1 HSPA6 P2RX7 IGHV3-13 ATP6V0C PELI2 VAPA HLA-B CLEC10A SIKE1 IGHV3-7 NFATC1 NPC2 IGHV3-11 PRDX4 HERC5 SERPINB3 TICAM1 CRK PSMB7 PLD3 CLEC7A LRMP MYO10 PELI3 PSMA5 S100P CD46 C2 APOB PIN1 MAPKAPK3
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Hierarchy Landscape

The following plot represents the hierarchical landscape of 'Innate Immune System'. The hierarchical tree allows to click on the pathways with children (black border) and continue the exploration. All nodes are colored by their source (click on the map for the legend) and cross-link to the original pathway page.

Sub-Pathways

About

ComPath is developed and maintained in an academic capacity by Daniel Domingo-Fernández and Charles Tapley Hoyt at the Fraunhofer SCAI Department of Bioinformatics. This web application relies on data loaded from KEGG, Reactome, and WikiPathways Restful APIs, as well as MSigDB. More information here.