Innate Immune System - Pathway Page
Name Innate Immune System
Resource Reactome
Genes FUCA1 PRG3 CREBBP NFATC2 POLR2F QSOX1 MUCL1 RNASE8 PTK2 RNF135 UBE2N ACTB ATP6V0A4 DEFB113 LRRFIP1 TXN AOC1 PGAM1 ENPP4 DEFB127 IGHV3-23 BPIFB2 ALOX5 HTN3 PSMB4 HSPA1A MUC15 PDZD11 MAGT1 PSMC4 MAPK11 C4A IGHV3-33 DEFA1 ATP6V0E1 BRK1 PSMD5 PPP3CB CASP2 ADGRE3 SEM1 ELANE ILF2 PTPN6 NFKBIB PSMC3 DTX4 CD53 SERPING1 MRE11 MAP2K6 UBC CYB5R3 BPIFA1 POLR1C TXNIP HRNR LAMP1 OLFM4 ATP6V1G3 ANO6 PRTN3 CFHR3 LILRB3 CD14 PPP2CA JUP ACTR3 PRKCD PKM RAB6A CSTB PLD3 TNFAIP6 SUGT1 KIR3DS1 NCF2 NKIRAS1 DEFB104A AMPD3 IFIH1 CASP10 PSMA4 IGLV3-1 WASF1 TEC DUSP6 PRKCSH KIR2DS4 IRF7 S100A9 NFASC IGKV1-17 UBA3 SNAP23 GUSB GAB2 LPCAT1 S100A11 IGHV3-48 LTA4H NLRC4 SIGLEC16 VCP CFHR1 RAB31 PECAM1 FBXW11 PSMD7 UBB IFNA2 PSME2 ARG1 RELA FPR1 IGKV2-30 PYCARD RHOF PTPRJ CD68 CALML5 ATP6V1D MAPK8 IGKV3D-20 RHOG CD247 UBE2K C1R PSMD13 PSMD3 IRAK2 MAPK9 CXCR2 HEBP2 CHIT1 MMP25 VAV2 UNC13D ITGAX LILRB2 FGA SURF4 HLA-H LEAP2 PLAC8 PSMD9 POLR3B ELMO1 TLR8 BRI3 TLR10 NLRP3 C5AR1 PGM1 MANBA APRT C7 PELI1 LYN IGHV4-34 TICAM2 IRAK1 RAC1 EEF2 CTSV DNM1 XRCC5 PSMC5 ATP6V1C1 MIF ATG7 CPB2 KCNAB2 CAPZA1 BIRC2 IGKV1D-16 STAT6 PRCP NCF4 ARMC8 BCL2L1 ATG5 TREX1 TNIP2 GHDC LAMP2 S100P CREB1 FGL2 SYK BPI TIMP2 PPP3R1 P2RX7 NFATC3 CD33 PIK3CB SERPINB1 TMC6 PLD1 PPP2CB IQGAP2 RAB3A LRG1 CFD PAFAH1B2 C1QB FOS NCR2 CD58 CFHR2 NCKAP1L GLA OSCAR CARD9 TSPAN14 CNN2 PLEKHO2 ATAD3B IGLV7-43 LBP DDX58 IGLV2-23 BAIAP2 ELMO2 MAP2K4 UBE2D2 CD81 TNFRSF1B WASL C4BPA DNAJC3 MME DEFB106A DEFB130B MUC12 CDK13 TIRAP C4B ORM2 BTRC MVP KIR2DS5 TRPM2 PGLYRP4 LY86 IDH1 UBE2M MLEC MBL2 DERA RAB7A SLCO4C1 POLR3A IGKV2-28 CRISP3 IKBKG IFNA5 KIR2DS2 NLRP1 DEFB103A MAPKAPK3 BPIFB6 ALAD ATP6V1C2 ALDOA IGKV2D-40 COTL1 DBNL PSMD4 IGKV1-33 MUC5B CST3 STOM SNAP29 DNAJC13 CR2 POLR3G DEFB128 PLPP5 FPR2 TICAM1 SAA1 POLR2K SLC2A5 SFTPA2 TCIRG1 CARD11 BTK TBK1 DEFB130A APAF1 CFP GZMM ADGRG3 MYO1C CALM1 COLEC11 UBR4 DEFB131A VTN MUC1 IGKC SDCBP SELL PSMC1 ELK1 TLR5 BCL10 CD46 PRKACA UBE2L6 EP300 PSEN1 PA2G4 PSMD1 KPNB1 NIT2 C2 HP RPS6KA3 ATP11B PELI3 CD55 RPS6KA1 ANXA2 REG3G ART1 FCER1A DOK3 CLEC12A RNF216 GM2A CLEC7A C8G IGKV1D-39 DEFB124 DEFB105A FYN ACAA1 IGLV1-47 NKIRAS2 TMEM30A IGHV2-70 RAB5B IGLV2-14 C8B ECSIT DEFB114 BCL2 MAPK12 HK3 DSP POLR2E ARPC1A PI3 IFNA21 ASAH1 POLR3GL IGHV4-39 FCN2 EPPIN NF2 MS4A2 VAV3 HERC5 SARM1 PSTPIP1 MOSPD2 SRP14 IGHV3-9 RIPK3 PSMB9 TRAPPC1 DUSP3 KLRK1 UBE2V1 DOCK2 MYO9B WIPF1 NCF1 ICAM3 HLA-A MAPK3 GRB2 MEF2A IGF2R IGHV2-5 CXCR1 CDC42 DEFB132 TANK CSNK2B CRISPLD2 IFNA17 MAPK7 PLA2G2A IGKV2-29 DEFB119 NFKB1 S100A7A CAMP TLR1 NCSTN DEFA4 CXCL1 POLR3K POLR3C CHUK XRCC6 AP2A2 IRAK4 PSMB1 GPI MAVS PSMD6 GCA NLRP4 CRCP RAB10 DUSP7 DEFA3 WASF3 MYO5A BPIFA2 POLR2H TMEM173 CPPED1 CYBA PRDX6 SKP1 DEFB125 SRC CTSC IGHV3-7 SERPINA1 S100A7 KLRD1 DPP7 NOD2 CLEC4E CASP1 HRAS NOD1 HMGB1 TRAF2 IGLV2-11 MEFV LTF TLR2 UBA52 SCAMP1 ADA2 RNASE3 IGHG4 FCAR TXNDC5 RASGRP1 CGAS FRMPD3 TRAF3 RPS27A B4GALT1 NHLRC3 ATP11A RAB27A IKBKB PYGL MUC17 ABI1 FCN3 STBD1 CYBB MALT1 PSMB8 CTSL MGST1 FTL IGHV1-69 TRIM25 PSMA6 TUBB4B TMEM179B QPCT OTUD5 CPN1 DGAT1 IGKV1-5 DHX36 IGKV3-15 ITLN1 HBB TBC1D10C RAB4B PYGB MYH2 S100B DSG1 IGKV1D-33 PROS1 PSMD8 CRP FLG2 DNM2 ARPC5 C5 WIPF3 DSC1 CR1 MYO10 TLR7 HEXB RNF125 IGLV6-57 RASGRP4 FCGR3A PSMB10 ARSA IFNA7 IGKV1-16 RNASE2 IFNA8 ATP6V1E1 LIMK1 MAPKAPK2 ATG12 PIGR ATP6V0B RAP1B ARPC1B GNS FCN1 AZU1 FADD SOS1 NEU1 MUC3B MAP2K7 RNASET2 SIGLEC15 HLA-C MAP3K14 PSMA8 GLB1 CD180 ITPR2 IGHV3-53 DEFB115 SLC44A2 TAB3 CCT2 RETN TOM1 HLA-B ALDOC KIR2DS1 GRN MASP2 HSPA1B LYZ CLEC6A PNP POLR3D C6 EEF1A1 PTPRB NLRC3 LAIR1 AHSG DNASE1L1 DEFB109B EPX DHX9 TUBB ARSB CYFIP1 BIN2 PLD4 MGAM IMPDH2 KRAS IFNA6 VRK3 MAN2B1 TRIM56 BIRC3 CKAP4 SERPINB3 FCGR2A MAPK14 DEFB110 PSMB2 VCL BPIFB4 RAB9B ACTG1 IFNA4 VPS35L CD59 RPS6KA5 IKBKE LAMTOR1 PTPN11 PAK3 SERPINA3 PDPK1 CD36 AHCYL1 CNPY3 IQGAP1 IFNA10 ATP8A1 HSP90AB1 NOS2 ITGB2 PTPN4 EEA1 DHX58 HMOX2 C6orf120 BST1 IGHV3-13 DEFB121 LGMN S100A12 NOS3 ATP6V1E2 IMPDH1 TAB1 POLR3F CFHR4 IGLV1-51 CASP8 JUN IGHV3-11 P2RX1 VAMP8 VAPA DEFB133 GDI2 ROCK1 ATP6V1B2 CDA APEH PTPRN2 CMTM6 REG3A PSMB3 ATP6V1A C3 IGKV4-1 FCGR1A HGSNAT CD3G ADAM8 MYD88 LGALS3 HTN1 CD4 KRT1 ATP6V0D2 CFI ARPC4 HSP90AA1 PDAP1 AGPAT2 AP1M1 CEACAM6 ACPP CYSTM1 TCN1 KLRC2 LCK IGLV3-25 CLEC10A DSN1 LAT RNASE7 IFI16 DDX3X SERPINB10 CPNE3 CRACR2A S100A8 MEF2C MUC4 PGLYRP3 SIRPA NLRC5 SOCS1 GYG1 IGLC6 PPP2R5D LRRC7 GAA IGKV3-20 LY96 PLPP4 GALNS PRKCQ TREM2 RAP2B RAB5C ATP6V0A1 MUC3A CHI3L1 MNDA YES1 PIK3C3 ITGAL TREM1 DEFB1 PGM2 MUC16 GGH METTL7A TLR6 FOLR3 NCKAP1 NCKIPSD DYNLL1 NPC2 MASP1 AGA TMEM63A ATF2 IGLV3-19 RAB37 FCER1G CLEC4A MAP2K3 PPP2R1A PPP3CA MAPK13 SEMG1 CFL1 ZBP1 PIK3CA CD44 DEFB112 IGKV1D-12 GSTP1 SIKE1 IST1 PSME4 BPIFB1 SFTPA1 RAB14 CFH LRMP RAB24 RIPK1 ACTR10 CHGA PGLYRP1 SIGIRR ATP7A PSMB5 FTH1 RAB18 TKFC CD19 IGKV1-12 IFNA14 VAV1 KCMF1 ALDH3B1 NME2 TLR3 RELB TLR9 IGKV1-39 SIGLEC14 CAND1 ARPC3 SERPINB6 PSMF1 CANT1 COLEC10 PIK3R2 PPP2R1B PRKCE POLR2L CTSB GMFG IGHV1-2 CD93 CD300LB PSMB7 IFNB1 CRK UBA7 IGKV3-11 PLD2 CCR2 CYLD DEGS1 APP ITCH IGHV3-30 MUC7 F2 CTSS WIPF2 A1BG PRSS2 PTX3 PPBP MMP9 ARHGAP45 MUC6 YPEL5 APOB CEACAM1 B2M CHRNB4 HVCN1 CYFIP2 ACLY FGB UNC93B1 DCD RNASE6 DEFA5 DDOST ITK IGHG1 BST2 STK11IP HLA-E CD300A SHC1 DYNLT1 CD47 COMMD9 PSMB11 ISG15 PSMA3 PTGES2 PRKDC IGLV3-27 ITPR3 GRAP2 DEFB135 ORM1 SFTPD PELI2 NAPRT COMMD3 DEFB107A CD209 IGHG3 SYNGR1 RAP2C CREG1 SIRPB1 MAP2K1 DNAJC5 NCK1 CLU DEFA6 VAT1 OLR1 PRG2 IFNA16 SVIP ATP8B4 CTSK C1S CFHR5 GNLY CAPZA2 AIM2 CTSH DEFB108B MUC19 CASP4 CCT8 DUSP4 PIN1 RAP1A C8A IFNA13 ATP6V0E2 RASGRP2 UBE2D1 ACTR2 DEFB4A CAB39 ITPR1 TNFAIP3 PPIE GSN PIK3R4 ICAM2 CAPN1 LCN2 DIAPH1 PGLYRP2 ABL1 PSMD2 CPN2 PRKACG LAMTOR3 PDXK DEFB118 PLA2G6 CTSD HSPA6 LAT2 TAX1BP1 C5AR2 ATOX1 ATF1 AGER SLC11A1 MS4A3 STK10 MPO FCGR3B S100A1 PTPRC MCEMP1 SLPI DOCK1 MAP3K1 ORMDL3 CLEC5A ANPEP MUC21 PLCG1 PSMD14 NOS1 ERP44 POLR3E ARPC2 MAPK10 PSMA2 IGLC1 ITGAV MYH9 TRIM21 PKP1 RAF1 SLC27A2 ATP6V0A2 FGR DEFB108A CTSG MAP3K8 TXK ATP6V1H PGRMC1 IGHV4-59 HUWE1 MUC2 CLEC4D GLIPR1 PSMB6 ADGRE5 ITGAM IGLV3-21 MUC20 NLRX1 TAB2 CEP290 LILRA3 GSDMD SLC15A4 NFKBIA CCR6 HPSE PIK3R1 PSAP PRSS3 DEFB136 UBE2D3 SIGLEC5 IGKV2D-28 PSME1 CEACAM3 CDC34 IGHG2 RBSN SLC2A3 PANX1 ADAM10 CEACAM8 NBEAL2 NFAM1 CUL1 ACTR1B COPB1 RAB44 PLAUR PAK2 PSMD11 ATP6V0C ABCA13 PCBP2 WAS MUC5AC C4BPB GOLGA7 WASF2 TRAF6 DYNC1LI1 TRIM32 FAF2 NFATC1 C3AR1 ATP6V1G1 PAK1 CD63 IGLV1-44 ATP6V1B1 SERPINB12 DDX41 ATP6AP2 CASP9 DYNC1H1 LCP2 AGL FGG CD177 CAP1 PSMA1 DEFB129 RHOA PSMA7 PSMC6 ABI2 IGHE MAP3K7 PLCG2 TTR CLEC4C RPS6KA2 PSME3 RIPK2 MUC13 C1QA CAT PRKACB DEFB126 OSTF1 TYROBP MMP8 DEFB134 POLR3H TARM1 CTSZ CTNNB1 IGKV5-2 PSMA5 IRAK3 ARHGAP9 C1orf35 FUCA2 ARL8A IL1B IRF3 IGLV1-40 IGLV2-8 PSMD10 IGLC7 PTAFR NFKB2 CPNE1 CD300E PRDX4 IGKV2D-30 SPTAN1 FABP5 C1QC RAB3D DEFB123 ATP6V1F PLAU PADI2 ATP6V0D1 HSP90B1 SNAP25 PSMC2 NRAS C9 TMBIM1 TLR4 DNM3 PSMD12 DEFB116 FRK VNN1 MAPK1 PFKL IGHV1-46 GPR84 HCK TOLLIP CFB HSPA8 NDUFC2 LAMTOR2 SIGLEC9 CTSA ATP6V1G2 PPIA
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Hierarchy Landscape

The following plot represents the hierarchical landscape of 'Innate Immune System'. The hierarchical tree allows to click on the pathways with children (black border) and continue the exploration. All nodes are colored by their source (click on the map for the legend) and cross-link to the original pathway page.

Sub-Pathways

About

ComPath is developed and maintained in an academic capacity by Daniel Domingo-Fernández and Charles Tapley Hoyt at the Fraunhofer SCAI Department of Bioinformatics. This web application relies on data loaded from KEGG, Reactome, and WikiPathways Restful APIs, as well as MSigDB. More information here.