Reactome Distribution Summary

Explore the distribution of the pathway sizes across different resources. The aim of this plot is just to show the distribution and the outliers, in order to inspect and find the name of the outliers, please use the table in the section below.

Explore the histogram in detail using the table below.

Pathway Name	Gene Set Size
2-LTR circle formation	13
5-Phosphoribose 1-diphosphate biosynthesis	3
A tetrasaccharide linker sequence is required for GAG synthesis	26
ABC transporter disorders	76
ABC transporters in lipid homeostasis	18
ABC-family proteins mediated transport	103
ADP signalling through P2Y purinoceptor 1	25
ADP signalling through P2Y purinoceptor 12	22
AKT phosphorylates targets in the cytosol	14
AKT phosphorylates targets in the nucleus	10
AKT-mediated inactivation of FOXO1A	4
ALKBH2 mediated reversal of alkylation damage	1
ALKBH3 mediated reversal of alkylation damage	4
AMER1 mutants destabilize the destruction complex	14
AMPK inhibits chREBP transcriptional activation activity	8
APC truncation mutants are not K63 polyubiquitinated	1
APC truncation mutants have impaired AXIN binding	14
APC-Cdc20 mediated degradation of Nek2A	25
APC/C-mediated degradation of cell cycle proteins	86
APC/C:Cdc20 mediated degradation of Cyclin B	23
APC/C:Cdc20 mediated degradation of Securin	67
APC/C:Cdc20 mediated degradation of mitotic proteins	75
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1	72
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint	73
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway	7
APOBEC3G mediated resistance to HIV-1 infection	12
ARL13B-mediated ciliary trafficking of INPP5E	3
ARMS-mediated activation	7
ATF4 activates genes	25
ATF6 (ATF6-alpha) activates chaperone genes	10
ATF6 (ATF6-alpha) activates chaperones	12
ATP sensitive Potassium channels	4
AUF1 (hnRNP D0) binds and destabilizes mRNA	56
AURKA Activation by TPX2	72
AXIN missense mutants destabilize the destruction complex	14
AXIN mutants destabilize the destruction complex, activating WNT signaling	14
Abacavir metabolism	5
Abacavir transmembrane transport	5
Abacavir transport and metabolism	10
Abasic sugar-phosphate removal via the single-nucleotide replacement pathway	2
Abnormal conversion of 2-oxoglutarate to 2-hydroxyglutarate	1
Abortive elongation of HIV-1 transcript in the absence of Tat	23
Acetylation	2
Acetylcholine Neurotransmitter Release Cycle	17
Acetylcholine binding and downstream events	14
Acetylcholine regulates insulin secretion	10
Acrosome Reaction	1
Activated NOTCH1 Transmits Signal to the Nucleus	31
Activated NTRK2 signals through CDK5	6
Activated NTRK2 signals through FRS2 and FRS3	11
Activated NTRK2 signals through FYN	7
Activated NTRK2 signals through PI3K	7
Activated NTRK2 signals through PLCG1	4
Activated NTRK2 signals through RAS	10
Activated NTRK3 signals through PI3K	6
Activated NTRK3 signals through PLCG1	3
Activated NTRK3 signals through RAS	9
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3	36
Activated point mutants of FGFR2	19
Activation and oligomerization of BAK protein	2
Activation of AKT2	4
Activation of AMPA receptors	4
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins	76
Activation of ATR in response to replication stress	37
Activation of BAD and translocation to mitochondria	15
Activation of BH3-only proteins	30
Activation of BIM and translocation to mitochondria	3
Activation of BMF and translocation to mitochondria	3
Activation of C3 and C5	7
Activation of Ca-permeable Kainate Receptor	10
Activation of CaMK IV	2
Activation of DNA fragmentation factor	13
Activation of E2F1 target genes at G1/S	28
Activation of G protein gated Potassium channels	25
Activation of GABAB receptors	39
Activation of HOX genes during differentiation	91
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon	17
Activation of Matrix Metalloproteinases	33
Activation of NF-kappaB in B cells	67
Activation of NIMA Kinases NEK9, NEK6, NEK7	7
Activation of NMDA receptor and postsynaptic events	39
Activation of NOXA and translocation to mitochondria	5
Activation of Na-permeable kainate receptors	2
Activation of Nicotinic Acetylcholine Receptors	14
Activation of PPARGC1A (PGC-1alpha) by phosphorylation	10
Activation of PUMA and translocation to mitochondria	9
Activation of RAC1	13
Activation of RAS in B cells	5
Activation of SMO	18
Activation of TRKA receptors	7
Activation of anterior HOX genes in hindbrain development during early embryogenesis	91
Activation of caspases through apoptosome-mediated cleavage	5
Activation of gene expression by SREBF (SREBP)	43
Activation of kainate receptors upon glutamate binding	30
Activation of the AP-1 family of transcription factors	10
Activation of the TFAP2 (AP-2) family of transcription factors	12
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S	60
Activation of the phototransduction cascade	11
Activation of the pre-replicative complex	33
Activation, myristolyation of BID and translocation to mitochondria	4
Activation, translocation and oligomerization of BAX	2
Acyl chain remodeling of CL	6
Acyl chain remodeling of DAG and TAG	8
Acyl chain remodelling of PC	27
Acyl chain remodelling of PE	29
Acyl chain remodelling of PG	18
Acyl chain remodelling of PI	17
Acyl chain remodelling of PS	22
Adaptive Immune System	944
Adenosine P1 receptors	4
Adenylate cyclase activating pathway	10
Adenylate cyclase inhibitory pathway	14
Adherens junctions interactions	33
Adrenaline signalling through Alpha-2 adrenergic receptor	3
Adrenaline,noradrenaline inhibits insulin secretion	28
Adrenoceptors	9
Advanced glycosylation endproduct receptor signaling	13
Aflatoxin activation and detoxification	20
Agmatine biosynthesis	2
Alpha-defensins	10
Alpha-oxidation of phytanate	6
Alternative complement activation	5
Amine Oxidase reactions	4
Amine ligand-binding receptors	43
Amine-derived hormones	18
Amino Acid conjugation	9
Amino acid synthesis and interconversion (transamination)	35
Amino acid transport across the plasma membrane	34
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal	94
Amplification of signal from the kinetochores	94
Amyloid fiber formation	71
Anchoring fibril formation	15
Anchoring of the basal body to the plasma membrane	97
Androgen biosynthesis	11
Antagonism of Activin by Follistatin	4
Antigen Presentation: Folding, assembly and peptide loading of class I MHC	93
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	100
Antigen processing-Cross presentation	168
Antigen processing: Ubiquitination & Proteasome degradation	309
Antimicrobial peptides	95
Antiviral mechanism by IFN-stimulated genes	78
Apoptosis	171
Apoptosis induced DNA fragmentation	13
Apoptotic cleavage of cell adhesion proteins	11
Apoptotic cleavage of cellular proteins	38
Apoptotic execution phase	52
Apoptotic factor-mediated response	7
Aquaporin-mediated transport	53
Arachidonate production from DAG	5
Arachidonic acid metabolism	59
Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2	1
Aryl hydrocarbon receptor signalling	7
Asparagine N-linked glycosylation	304
Assembly Of The HIV Virion	24
Assembly of Viral Components at the Budding Site	7
Assembly of active LPL and LIPC lipase complexes	19
Assembly of collagen fibrils and other multimeric structures	61
Assembly of the ORC complex at the origin of replication	6
Assembly of the pre-replicative complex	68
Association of TriC/CCT with target proteins during biosynthesis	39
Astrocytic Glutamate-Glutamine Uptake And Metabolism	4
Asymmetric localization of PCP proteins	64
Attachment of GPI anchor to uPAR	7
Attenuation phase	14
Autodegradation of Cdh1 by Cdh1:APC/C	63
Autodegradation of the E3 ubiquitin ligase COP1	52
Autointegration results in viral DNA circles	9
Axon guidance	556
Axonal growth inhibition (RHOA activation)	9
Axonal growth stimulation	4
B-WICH complex positively regulates rRNA expression	60
BBSome-mediated cargo-targeting to cilium	23
BDNF activates NTRK2 (TRKB) signaling	2
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members	9
BMAL1:CLOCK,NPAS2 activates circadian gene expression	27
Base Excision Repair	39
Base-Excision Repair, AP Site Formation	11
Basigin interactions	25
Beta defensins	39
Beta oxidation of butanoyl-CoA to acetyl-CoA	5
Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA	6
Beta oxidation of hexanoyl-CoA to butanoyl-CoA	5
Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA	5
Beta oxidation of myristoyl-CoA to lauroyl-CoA	3
Beta oxidation of octanoyl-CoA to hexanoyl-CoA	5
Beta oxidation of palmitoyl-CoA to myristoyl-CoA	3
Beta-catenin independent WNT signaling	143
Beta-catenin phosphorylation cascade	17
Beta-oxidation of pristanoyl-CoA	9
Beta-oxidation of very long chain fatty acids	11
Bicarbonate transporters	10
Bile acid and bile salt metabolism	43
Binding and Uptake of Ligands by Scavenger Receptors	129
Binding and entry of HIV virion	12
Binding of TCF/LEF:CTNNB1 to target gene promoters	8
Biogenic amines are oxidatively deaminated to aldehydes by MAOA and MAOB	2
Biological oxidations	223
Biosynthesis of A2E, implicated in retinal degradation	1
Biosynthesis of D-series resolvins	4
Biosynthesis of DHA-derived SPMs	17
Biosynthesis of DHA-derived sulfido conjugates	2
Biosynthesis of DPA-derived SPMs	4
Biosynthesis of DPAn-3 SPMs	4
Biosynthesis of DPAn-3-derived 13-series resolvins	1
Biosynthesis of DPAn-3-derived maresins	2
Biosynthesis of DPAn-3-derived protectins and resolvins	2
Biosynthesis of DPAn-6 SPMs	2
Biosynthesis of E-series 18(R)-resolvins	4
Biosynthesis of E-series 18(S)-resolvins	5
Biosynthesis of EPA-derived SPMs	6
Biosynthesis of aspirin-triggered D-series resolvins	3
Biosynthesis of electrophilic ω-3 PUFA oxo-derivatives	2
Biosynthesis of maresin conjugates in tissue regeneration (MCTR)	2
Biosynthesis of maresin-like SPMs	6
Biosynthesis of maresins	8
Biosynthesis of protectin and resolvin conjugates in tissue regeneration (PCTR and RCTR)	1
Biosynthesis of protectins	4
Biosynthesis of specialized proresolving mediators (SPMs)	19
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein	78
Biotin transport and metabolism	11
Branched-chain amino acid catabolism	23
Breakdown of the nuclear lamina	3
Budding	9
Budding and maturation of HIV virion	36
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA	17
Butyrophilin (BTN) family interactions	12
C-type lectin receptors (CLRs)	173
C6 deamination of adenosine	2
CASP8 activity is inhibited	14
CD209 (DC-SIGN) signaling	21
CD22 mediated BCR regulation	70
CD28 co-stimulation	33
CD28 dependent PI3K/Akt signaling	22
CD28 dependent Vav1 pathway	12
CDC6 association with the ORC:origin complex	11
CDK-mediated phosphorylation and removal of Cdc6	72
CDO in myogenesis	29
CDT1 association with the CDC6:ORC:origin complex	59
CHL1 interactions	9
CLEC7A (Dectin-1) induces NFAT activation	11
CLEC7A (Dectin-1) signaling	98
CLEC7A/inflammasome pathway	6
COPI-dependent Golgi-to-ER retrograde traffic	102
COPI-independent Golgi-to-ER retrograde traffic	52
COPI-mediated anterograde transport	101
COPII-mediated vesicle transport	68
COX reactions	1
CREB phosphorylation	7
CREB phosphorylation through the activation of Adenylate Cyclase	7
CREB phosphorylation through the activation of CaMKII	15
CREB phosphorylation through the activation of CaMKK	4
CREB phosphorylation through the activation of Ras	27
CREB3 factors activate genes	9
CRMPs in Sema3A signaling	16
CS/DS degradation	14
CTLA4 inhibitory signaling	21
CYP2E1 reactions	11
Ca-dependent events	28
Ca2+ activated K+ channels	9
Ca2+ pathway	59
CaM pathway	26
CaMK IV-mediated phosphorylation of CREB	3
Calcineurin activates NFAT	9
Calcitonin-like ligand receptors	11
Calmodulin induced events	26
Calnexin/calreticulin cycle	26
Cam-PDE 1 activation	4
Cap-dependent Translation Initiation	120
Carboxyterminal post-translational modifications of tubulin	42
Cardiac conduction	140
Cargo concentration in the ER	33
Cargo recognition for clathrin-mediated endocytosis	99
Cargo trafficking to the periciliary membrane	51
Carnitine synthesis	4
Caspase activation via extrinsic apoptotic signalling pathway	29
Caspase-mediated cleavage of cytoskeletal proteins	12
Catecholamine biosynthesis	4
Cation-coupled Chloride cotransporters	7
Cdc20:Phospho-APC/C mediated degradation of Cyclin A	72
Cell Cycle	621
Cell Cycle Checkpoints	274
Cell Cycle, Mitotic	514
Cell death signalling via NRAGE, NRIF and NADE	76
Cell junction organization	92
Cell redox homeostasis	9
Cell surface interactions at the vascular wall	245
Cell-Cell communication	130
Cell-cell junction organization	65
Cell-extracellular matrix interactions	18
Cellular Senescence	164
Cellular hexose transport	21
Cellular response to heat stress	93
Cellular response to hypoxia	75
Cellular responses to external stimuli	482
Cellular responses to stress	405
Centrosome maturation	81
Ceramide signalling	3
ChREBP activates metabolic gene expression	8
Chaperonin-mediated protein folding	95
Chemokine receptors bind chemokines	48
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex	13
Cholesterol biosynthesis	26
Cholesterol biosynthesis via desmosterol	4
Cholesterol biosynthesis via lathosterol	4
Choline catabolism	6
Chondroitin sulfate biosynthesis	20
Chondroitin sulfate/dermatan sulfate metabolism	50
Chromatin modifying enzymes	241
Chromatin organization	241
Chromosome Maintenance	90
Chylomicron assembly	10
Chylomicron clearance	5
Chylomicron remodeling	10
Cilium Assembly	201
Circadian Clock	68
Citric acid cycle (TCA cycle)	22
Class A/1 (Rhodopsin-like receptors)	324
Class B/2 (Secretin family receptors)	97
Class C/3 (Metabotropic glutamate/pheromone receptors)	40
Class I MHC mediated antigen processing & presentation	440
Classical Kir channels	4
Classical antibody-mediated complement activation	95
Clathrin derived vesicle budding	74
Clathrin-mediated endocytosis	139
Clearance of Nuclear Envelope Membranes from Chromatin	10
Cleavage of Growing Transcript in the Termination Region	66
Cleavage of the damaged purine	4
Cleavage of the damaged pyrimidine	8
Cobalamin (Cbl, vitamin B12) transport and metabolism	21
Coenzyme A biosynthesis	8
Cohesin Loading onto Chromatin	10
Collagen biosynthesis and modifying enzymes	67
Collagen chain trimerization	44
Collagen degradation	64
Collagen formation	90
Common Pathway of Fibrin Clot Formation	22
Competing endogenous RNAs (ceRNAs) regulate PTEN translation	8
Complement cascade	146
Complex I biogenesis	55
Condensation of Prometaphase Chromosomes	11
Condensation of Prophase Chromosomes	45
Conjugation of benzoate with glycine	6
Conjugation of carboxylic acids	9
Conjugation of phenylacetate with glutamine	2
Conjugation of salicylate with glycine	8
Constitutive Signaling by AKT1 E17K in Cancer	26
Constitutive Signaling by Aberrant PI3K in Cancer	79
Constitutive Signaling by EGFRvIII	15
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants	19
Constitutive Signaling by NOTCH1 HD Domain Mutants	15
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants	59
Constitutive Signaling by NOTCH1 PEST Domain Mutants	59
Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant	7
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase	19
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding	42
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding	32
Costimulation by the CD28 family	88
Creatine metabolism	10
Creation of C4 and C2 activators	103
Cristae formation	31
Cross-presentation of particulate exogenous antigens (phagosomes)	8
Cross-presentation of soluble exogenous antigens (endosomes)	50
Crosslinking of collagen fibrils	18
Cyclin A/B1/B2 associated events during G2/M transition	25
Cyclin A:Cdk2-associated events at S phase entry	85
Cyclin D associated events in G1	44
Cyclin E associated events during G1/S transition	83
Cysteine formation from homocysteine	2
Cytochrome P450 - arranged by substrate type	65
Cytochrome c-mediated apoptotic response	5
Cytokine Signaling in Immune system	771
Cytosolic iron-sulfur cluster assembly	13
Cytosolic sensors of pathogen-associated DNA	63
Cytosolic sulfonation of small molecules	25
Cytosolic tRNA aminoacylation	24
DAG and IP3 signaling	32
DAP12 interactions	46
DAP12 signaling	29
DARPP-32 events	24
DCC mediated attractive signaling	14
DDX58/IFIH1-mediated induction of interferon-alpha/beta	77
DEx/H-box helicases activate type I IFN and inflammatory cytokines production	7
DNA Damage Bypass	49
DNA Damage Recognition in GG-NER	38
DNA Damage Reversal	8
DNA Damage/Telomere Stress Induced Senescence	61
DNA Double Strand Break Response	60
DNA Double-Strand Break Repair	148
DNA Repair	296
DNA Replication	127
DNA Replication Pre-Initiation	85
DNA methylation	34
DNA replication initiation	8
DNA strand elongation	32
DSCAM interactions	11
Deactivation of the beta-catenin transactivating complex	42
Deadenylation of mRNA	25
Deadenylation-dependent mRNA decay	56
Death Receptor Signalling	147
Dectin-1 mediated noncanonical NF-kB signaling	60
Dectin-2 family	61
Defective ABCA1 causes Tangier disease	1
Defective ABCA12 causes autosomal recessive congenital ichthyosis type 4B	1
Defective ABCA3 causes pulmonary surfactant metabolism dysfunction 3 (SMDP3)	1
Defective ABCA3 causes pulmonary surfactant metabolism dysfunction type 3 (SMDP3)	1
Defective ABCB11 causes progressive familial intrahepatic cholestasis 2 and benign recurrent intrahepatic cholestasis 2	1
Defective ABCB4 causes progressive familial intrahepatic cholestasis 3, intrahepatic cholestasis of pregnancy 3 and gallbladder disease 1	1
Defective ABCB6 causes isolated colobomatous microphthalmia 7 (MCOPCB7)	1
Defective ABCC2 causes Dubin-Johnson syndrome	1
Defective ABCC6 causes pseudoxanthoma elasticum (PXE)	1
Defective ABCC8 can cause hypoglycemias and hyperglycemias	2
Defective ABCC9 causes dilated cardiomyopathy 10, familial atrial fibrillation 12 and hypertrichotic osteochondrodysplasia	1
Defective ABCD1 causes adrenoleukodystrophy (ALD)	1
Defective ABCD4 causes methylmalonic aciduria and homocystinuria, cblj type (MAHCJ)	1
Defective ABCG5 causes sitosterolemia	2
Defective ABCG8 causes gallbladder disease 4 and sitosterolemia	2
Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD)	2
Defective ACY1 causes encephalopathy	1
Defective AHCY causes Hypermethioninemia with S-adenosylhomocysteine hydrolase deficiency (HMAHCHD)	1
Defective ALG1 causes ALG1-CDG (CDG-1k)	1
Defective ALG11 causes ALG11-CDG (CDG-1p)	1
Defective ALG12 causes ALG12-CDG (CDG-1g)	1
Defective ALG14 causes congenital myasthenic syndrome (ALG14-CMS)	2
Defective ALG2 causes ALG2-CDG (CDG-1i)	1
Defective ALG3 causes ALG3-CDG (CDG-1d)	1
Defective ALG6 causes ALG6-CDG (CDG-1c)	1
Defective ALG8 causes ALG8-CDG (CDG-1h)	1
Defective ALG9 causes ALG9-CDG (CDG-1l)	1
Defective AMN causes hereditary megaloblastic anemia 1	3
Defective AVP causes neurohypophyseal diabetes insipidus (NDI)	2
Defective AVP causes neurohypophyseal diabetes insipidus (NDI)	3
Defective B3GALT6 causes EDSP2 and SEMDJL1	20
Defective B3GALTL causes Peters-plus syndrome (PpS)	38
Defective B3GAT3 causes JDSSDHD	20
Defective B4GALT1 causes B4GALT1-CDG (CDG-2d)	8
Defective B4GALT1 causes B4GALT1-CDG (CDG-2d)	1
Defective B4GALT7 causes EDS, progeroid type	20
Defective BTD causes biotidinase deficiency	1
Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS)	19
Defective CD320 causes methylmalonic aciduria	2
Defective CFTR causes cystic fibrosis	61
Defective CHST14 causes EDS, musculocontractural type	8
Defective CHST3 causes SEDCJD	8
Defective CHST6 causes MCDC1	8
Defective CHSY1 causes TPBS	8
Defective CP causes aceruloplasminemia (ACERULOP)	1
Defective CSF2RA causes pulmonary surfactant metabolism dysfunction 4 (SMDP4)	8
Defective CSF2RB causes pulmonary surfactant metabolism dysfunction 5 (SMDP5)	8
Defective CUBN causes hereditary megaloblastic anemia 1	3
Defective CYP11A1 causes Adrenal insufficiency, congenital, with 46,XY sex reversal (AICSR)	4
Defective CYP11B1 causes Adrenal hyperplasia 4 (AH4)	1
Defective CYP11B2 causes Corticosterone methyloxidase 1 deficiency (CMO-1 deficiency)	1
Defective CYP17A1 causes Adrenal hyperplasia 5 (AH5)	1
Defective CYP19A1 causes Aromatase excess syndrome (AEXS)	1
Defective CYP1B1 causes Glaucoma	1
Defective CYP21A2 causes Adrenal hyperplasia 3 (AH3)	1
Defective CYP24A1 causes Hypercalcemia, infantile (HCAI)	1
Defective CYP26B1 causes Radiohumeral fusions with other skeletal and craniofacial anomalies (RHFCA)	1
Defective CYP26C1 causes Focal facial dermal dysplasia 4 (FFDD4)	1
Defective CYP27A1 causes Cerebrotendinous xanthomatosis (CTX)	1
Defective CYP27B1 causes Rickets vitamin D-dependent 1A (VDDR1A)	1
Defective CYP2R1 causes Rickets vitamin D-dependent 1B (VDDR1B)	1
Defective CYP2U1 causes Spastic paraplegia 56, autosomal recessive (SPG56)	1
Defective CYP4F22 causes Ichthyosis, congenital, autosomal recessive 5 (ARCI5)	1
Defective CYP7B1 causes Spastic paraplegia 5A, autosomal recessive (SPG5A) and Congenital bile acid synthesis defect 3 (CBAS3)	1
Defective DHDDS causes retinitis pigmentosa 59	1
Defective DOLK causes DOLK-CDG (CDG-1m)	1
Defective DPAGT1 causes DPAGT1-CDG (CDG-1j) and CMSTA2	1
Defective DPM1 causes DPM1-CDG (CDG-1e)	1
Defective DPM2 causes DPM2-CDG (CDG-1u)	1
Defective DPM3 causes DPM3-CDG (CDG-1o)	1
Defective EXT1 causes exostoses 1, TRPS2 and CHDS	14
Defective EXT2 causes exostoses 2	14
Defective FMO3 causes Trimethylaminuria (TMAU)	1
Defective GALE can cause Epimerase-deficiency galactosemia (EDG)	1
Defective GALK1 can cause Galactosemia II (GALCT2)	1
Defective GALNT12 causes colorectal cancer 1 (CRCS1)	19
Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC)	19
Defective GALT can cause Galactosemia	1
Defective GCK causes maturity-onset diabetes of the young 2 (MODY2)	1
Defective GCLC causes Hemolytic anemia due to gamma-glutamylcysteine synthetase deficiency (HAGGSD)	1
Defective GFPT1 causes CMSTA1	1
Defective GGT1 causes Glutathionuria (GLUTH)	1
Defective GGT1 causes Glutathionuria (GLUTH)	1
Defective GIF causes intrinsic factor deficiency	1
Defective GNE causes sialuria, Nonaka myopathy and inclusion body myopathy 2	1
Defective GSS causes Glutathione synthetase deficiency (GSS deficiency)	1
Defective HEXA causes GM2G1	1
Defective HEXB causes GM2G2	1
Defective HK1 causes hexokinase deficiency (HK deficiency)	1
Defective HLCS causes multiple carboxylase deficiency	7
Defective LARGE causes MDDGA6 and MDDGB6	1
Defective LFNG causes SCDO3	5
Defective LMBRD1 causes methylmalonic aciduria and homocystinuria type cblF	1
Defective MAN1B1 causes MRT15	1
Defective MAOA causes Brunner syndrome (BRUNS)	1
Defective MAT1A causes Methionine adenosyltransferase deficiency (MATD)	1
Defective MGAT2 causes MGAT2-CDG (CDG-2a)	1
Defective MMAA causes methylmalonic aciduria type cblA	2
Defective MMAB causes methylmalonic aciduria type cblB	1
Defective MMACHC causes methylmalonic aciduria and homocystinuria type cblC	1
Defective MMADHC causes methylmalonic aciduria and homocystinuria type cblD	2
Defective MOGS causes MOGS-CDG (CDG-2b)	1
Defective MPDU1 causes MPDU1-CDG (CDG-1f)	1
Defective MPI causes MPI-CDG (CDG-1b)	1
Defective MTR causes methylmalonic aciduria and homocystinuria type cblG	2
Defective MTRR causes methylmalonic aciduria and homocystinuria type cblE	2
Defective MUT causes methylmalonic aciduria mut type	2
Defective Mismatch Repair Associated With MLH1	2
Defective Mismatch Repair Associated With MSH2	3
Defective Mismatch Repair Associated With MSH3	2
Defective Mismatch Repair Associated With MSH6	2
Defective Mismatch Repair Associated With PMS2	2
Defective NEU1 causes sialidosis	1
Defective OPLAH causes 5-oxoprolinase deficiency (OPLAHD)	1
Defective PAPSS2 causes SEMD-PA	1
Defective PGM1 causes PGM1-CDG (CDG1t)	1
Defective PMM2 causes PMM2-CDG (CDG-1a)	1
Defective POMGNT1 causes MDDGA3, MDDGB3 and MDDGC3	2
Defective POMT1 causes MDDGA1, MDDGB1 and MDDGC1	2
Defective POMT2 causes MDDGA2, MDDGB2 and MDDGC2	2
Defective RFT1 causes RFT1-CDG (CDG-1n)	1
Defective RHAG causes regulator type Rh-null hemolytic anemia (RHN)	1
Defective SFTPA2 causes idiopathic pulmonary fibrosis (IPF)	2
Defective SLC11A2 causes hypochromic microcytic anemia, with iron overload 1 (AHMIO1)	1
Defective SLC12A1 causes Bartter syndrome 1 (BS1)	1
Defective SLC12A3 causes Gitelman syndrome (GS)	1
Defective SLC12A6 causes agenesis of the corpus callosum, with peripheral neuropathy (ACCPN)	1
Defective SLC16A1 causes symptomatic deficiency in lactate transport (SDLT)	1
Defective SLC17A5 causes Salla disease (SD) and ISSD	1
Defective SLC17A8 causes autosomal dominant deafness 25 (DFNA25)	1
Defective SLC1A1 is implicated in schizophrenia 18 (SCZD18) and dicarboxylic aminoaciduria (DCBXA)	1
Defective SLC1A3 causes episodic ataxia 6 (EA6)	1
Defective SLC20A2 causes idiopathic basal ganglia calcification 1 (IBGC1)	1
Defective SLC22A12 causes renal hypouricemia 1 (RHUC1)	1
Defective SLC22A18 causes lung cancer (LNCR) and embryonal rhabdomyosarcoma 1 (RMSE1)	1
Defective SLC22A5 causes systemic primary carnitine deficiency (CDSP)	1
Defective SLC24A1 causes congenital stationary night blindness 1D (CSNB1D)	1
Defective SLC24A4 causes hypomineralized amelogenesis imperfecta (AI)	1
Defective SLC24A5 causes oculocutaneous albinism 6 (OCA6)	1
Defective SLC26A2 causes chondrodysplasias	1
Defective SLC26A3 causes congenital secretory chloride diarrhea 1 (DIAR1)	1
Defective SLC26A4 causes Pendred syndrome (PDS)	1
Defective SLC27A4 causes ichthyosis prematurity syndrome (IPS)	1
Defective SLC29A3 causes histiocytosis-lymphadenopathy plus syndrome (HLAS)	1
Defective SLC2A1 causes GLUT1 deficiency syndrome 1 (GLUT1DS1)	1
Defective SLC2A10 causes arterial tortuosity syndrome (ATS)	1
Defective SLC2A2 causes Fanconi-Bickel syndrome (FBS)	1
Defective SLC2A9 causes hypouricemia renal 2 (RHUC2)	1
Defective SLC33A1 causes spastic paraplegia 42 (SPG42)	1
Defective SLC34A1 causes hypophosphatemic nephrolithiasis/osteoporosis 1 (NPHLOP1)	1
Defective SLC34A2 causes pulmonary alveolar microlithiasis (PALM)	1
Defective SLC34A2 causes pulmonary alveolar microlithiasis (PALM)	1
Defective SLC34A3 causes Hereditary hypophosphatemic rickets with hypercalciuria (HHRH)	1
Defective SLC35A1 causes congenital disorder of glycosylation 2F (CDG2F)	1
Defective SLC35A1 causes congenital disorder of glycosylation 2F (CDG2F)	1
Defective SLC35A2 causes congenital disorder of glycosylation 2M (CDG2M)	1
Defective SLC35A3 causes arthrogryposis, mental retardation, and seizures (AMRS)	1
Defective SLC35C1 causes congenital disorder of glycosylation 2C (CDG2C)	1
Defective SLC35D1 causes Schneckenbecken dysplasia (SCHBCKD)	1
Defective SLC36A2 causes iminoglycinuria (IG) and hyperglycinuria (HG)	1
Defective SLC39A4 causes acrodermatitis enteropathica, zinc-deficiency type (AEZ)	1
Defective SLC3A1 causes cystinuria (CSNU)	1
Defective SLC40A1 causes hemochromatosis 4 (HFE4) (duodenum)	1
Defective SLC40A1 causes hemochromatosis 4 (HFE4) (macrophages)	1
Defective SLC4A1 causes hereditary spherocytosis type 4 (HSP4), distal renal tubular acidosis (dRTA) and dRTA with hemolytic anemia (dRTA-HA)	1
Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA)	1
Defective SLC5A1 causes congenital glucose/galactose malabsorption (GGM)	1
Defective SLC5A2 causes renal glucosuria (GLYS1)	1
Defective SLC5A5 causes thyroid dyshormonogenesis 1 (TDH1)	1
Defective SLC5A7 causes distal hereditary motor neuronopathy 7A (HMN7A)	1
Defective SLC5A7 causes distal hereditary motor neuronopathy 7A (HMN7A)	1
Defective SLC6A18 may confer susceptibility to iminoglycinuria and/or hyperglycinuria	1
Defective SLC6A18 may confer susceptibility to iminoglycinuria and/or hyperglycinuria	1
Defective SLC6A19 causes Hartnup disorder (HND)	1
Defective SLC6A19 causes Hartnup disorder (HND)	1
Defective SLC6A2 causes orthostatic intolerance (OI)	1
Defective SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS)	1
Defective SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS)	1
Defective SLC6A5 causes hyperekplexia 3 (HKPX3)	1
Defective SLC7A7 causes lysinuric protein intolerance (LPI)	1
Defective SLC7A9 causes cystinuria (CSNU)	1
Defective SLC9A6 causes X-linked, syndromic mental retardation,, Christianson type (MRXSCH)	1
Defective SLC9A9 causes autism 16 (AUTS16)	1
Defective SLCO1B1 causes hyperbilirubinemia, Rotor type (HBLRR)	1
Defective SLCO1B1 causes hyperbilirubinemia, Rotor type (HBLRR)	2
Defective SLCO1B3 causes hyperbilirubinemia, Rotor type (HBLRR)	2
Defective SLCO2A1 causes primary, autosomal recessive hypertrophic osteoarthropathy 2 (PHOAR2)	1
Defective SRD5A3 causes SRD5A3-CDG (CDG-1q) and KHRZ	1
Defective ST3GAL3 causes MCT12 and EIEE15	8
Defective TBXAS1 causes Ghosal hematodiaphyseal dysplasia (GHDD)	1
Defective TCN2 causes hereditary megaloblastic anemia	1
Defective TPMT causes Thiopurine S-methyltransferase deficiency (TPMT deficiency)	1
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)	3
Defective UGT1A1 causes hyperbilirubinemia	1
Defective UGT1A4 causes hyperbilirubinemia	1
Defective pro-SFTPB causes pulmonary surfactant metabolism dysfunction 1 (SMDP1) and respiratory distress syndrome (RDS)	3
Defective pro-SFTPC causes pulmonary surfactant metabolism dysfunction 2 (SMDP2) and respiratory distress syndrome (RDS)	2
Defects in biotin (Btn) metabolism	8
Defects in cobalamin (B12) metabolism	14
Defects in vitamin and cofactor metabolism	22
Defensins	49
Degradation of AXIN	55
Degradation of DVL	57
Degradation of GABA	2
Degradation of GLI1 by the proteasome	60
Degradation of GLI2 by the proteasome	60
Degradation of beta-catenin by the destruction complex	82
Degradation of cysteine and homocysteine	14
Degradation of the extracellular matrix	140
Depolymerisation of the Nuclear Lamina	16
Deposition of new CENPA-containing nucleosomes at the centromere	54
Depurination	4
Depyrimidination	8
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models	23
Dermatan sulfate biosynthesis	11
Detoxification of Reactive Oxygen Species	39
Deubiquitination	282
Developmental Biology	1053
Digestion	22
Digestion and absorption	27
Digestion of dietary carbohydrate	10
Digestion of dietary lipid	7
Dimerization of procaspase-8	11
Disassembly of the destruction complex and recruitment of AXIN to the membrane	31
Disease	1148
Diseases associated with N-glycosylation of proteins	17
Diseases associated with O-glycosylation of proteins	69
Diseases associated with glycosaminoglycan metabolism	41
Diseases associated with glycosylation precursor biosynthesis	15
Diseases associated with surfactant metabolism	12
Diseases associated with the TLR signaling cascade	26
Diseases associated with visual transduction	13
Diseases of Immune System	26
Diseases of Mismatch Repair (MMR)	5
Diseases of carbohydrate metabolism	34
Diseases of glycosylation	141
Diseases of metabolism	105
Diseases of signal transduction	392
Disinhibition of SNARE formation	5
Disorders of transmembrane transporters	144
Displacement of DNA glycosylase by APEX1	10
Dissolution of Fibrin Clot	13
Dopamine Neurotransmitter Release Cycle	23
Dopamine clearance from the synaptic cleft	4
Dopamine receptors	5
Downregulation of ERBB2 signaling	32
Downregulation of ERBB2:ERBB3 signaling	14
Downregulation of ERBB4 signaling	10
Downregulation of SMAD2/3:SMAD4 transcriptional activity	23
Downregulation of TGF-beta receptor signaling	26
Downstream TCR signaling	116
Downstream signal transduction	30
Downstream signaling events of B Cell Receptor (BCR)	81
Downstream signaling of activated FGFR1	34
Downstream signaling of activated FGFR2	34
Downstream signaling of activated FGFR3	27
Downstream signaling of activated FGFR4	28
Dual Incision in GG-NER	41
Dual incision in TC-NER	65
E2F mediated regulation of DNA replication	22
E2F-enabled inhibition of pre-replication complex formation	9
E3 ubiquitin ligases ubiquitinate target proteins	59
ECM proteoglycans	76
EGFR Transactivation by Gastrin	9
EGFR downregulation	25
EGFR interacts with phospholipase C-gamma	3
EPH-Ephrin signaling	92
EPH-ephrin mediated repulsion of cells	51
EPHA-mediated growth cone collapse	29
EPHB-mediated forward signaling	42
ER Quality Control Compartment (ERQC)	21
ER to Golgi Anterograde Transport	154
ER-Phagosome pathway	152
ERBB2 Activates PTK6 Signaling	16
ERBB2 Regulates Cell Motility	18
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression	45
ERK/MAPK targets	22
ERKs are inactivated	13
ESR-mediated signaling	126
Early Phase of HIV Life Cycle	22
Effects of PIP2 hydrolysis	27
Eicosanoid ligand-binding receptors	15
Eicosanoids	12
Elastic fibre formation	45
Electric Transmission Across Gap Junctions	5
Electron transport from NADPH to Ferredoxin	3
Elevation of cytosolic Ca2+ levels	16
Endogenous sterols	27
Endosomal Sorting Complex Required For Transport (ESCRT)	31
Endosomal/Vacuolar pathway	79
Energy dependent regulation of mTOR by LKB1-AMPK	29
Entry of Influenza Virion into Host Cell via Endocytosis	11
Enzymatic degradation of Dopamine by monoamine oxidase	2
Enzymatic degradation of dopamine by COMT	3
Ephrin signaling	19
Epigenetic regulation of gene expression	117
Erythrocytes take up carbon dioxide and release oxygen	12
Erythrocytes take up oxygen and release carbon dioxide	8
Essential fructosuria	1
Essential pentosuria	1
Establishment of Sister Chromatid Cohesion	11
Estrogen biosynthesis	6
Estrogen-dependent gene expression	120
Ethanol oxidation	12
Eukaryotic Translation Elongation	95
Eukaryotic Translation Initiation	120
Eukaryotic Translation Termination	94
Export of Viral Ribonucleoproteins from Nucleus	41
Expression and Processing of Neurotrophins	4
Extension of Telomeres	30
Extracellular matrix organization	301
Extrinsic Pathway of Fibrin Clot Formation	5
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis	55
FBXW7 Mutants and NOTCH1 in Cancer	6
FCERI mediated Ca+2 mobilization	117
FCERI mediated MAPK activation	118
FCERI mediated NF-kB activation	167
FCGR activation	101
FGFR1 ligand binding and activation	18
FGFR1 mutant receptor activation	33
FGFR1b ligand binding and activation	6
FGFR1c and Klotho ligand binding and activation	4
FGFR1c ligand binding and activation	12
FGFR2 alternative splicing	26
FGFR2 ligand binding and activation	23
FGFR2 mutant receptor activation	38
FGFR2b ligand binding and activation	11
FGFR2c ligand binding and activation	14
FGFR3 ligand binding and activation	14
FGFR3 mutant receptor activation	14
FGFR3b ligand binding and activation	7
FGFR3c ligand binding and activation	13
FGFR4 ligand binding and activation	14
FGFR4 mutant receptor activation	1
FGFRL1 modulation of FGFR1 signaling	13
FMO oxidises nucleophiles	3
FRS-mediated FGFR1 signaling	25
FRS-mediated FGFR2 signaling	28
FRS-mediated FGFR3 signaling	21
FRS-mediated FGFR4 signaling	22
Factors involved in megakaryocyte development and platelet production	159
Fanconi Anemia Pathway	38
FasL/ CD95L signaling	5
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion	8
Fatty acid metabolism	179
Fatty acids	15
Fatty acyl-CoA biosynthesis	37
Fc epsilon receptor (FCERI) signaling	217
Fcgamma receptor (FCGR) dependent phagocytosis	175
Fertilization	26
Fibronectin matrix formation	6
Ficolins bind to repetitive carbohydrate structures on the target cell surface	5
Folding of actin by CCT/TriC	10
Formation of ATP by chemiosmotic coupling	18
Formation of Fibrin Clot (Clotting Cascade)	39
Formation of HIV elongation complex in the absence of HIV Tat	48
Formation of HIV-1 elongation complex containing HIV-1 Tat	47
Formation of Incision Complex in GG-NER	43
Formation of RNA Pol II elongation complex	61
Formation of Senescence-Associated Heterochromatin Foci (SAHF)	16
Formation of TC-NER Pre-Incision Complex	53
Formation of a pool of free 40S subunits	102
Formation of annular gap junctions	11
Formation of apoptosome	3
Formation of editosomes by ADAR proteins	2
Formation of the Early Elongation Complex	33
Formation of the Editosome	8
Formation of the HIV-1 Early Elongation Complex	33
Formation of the active cofactor, UDP-glucuronate	3
Formation of the beta-catenin:TCF transactivating complex	60
Formation of the cornified envelope	129
Formation of the ternary complex, and subsequently, the 43S complex	52
Formation of tubulin folding intermediates by CCT/TriC	25
Formation of xylulose-5-phosphate	5
Formyl peptide receptors bind formyl peptides and many other ligands	9
Free fatty acid receptors	5
Free fatty acids regulate insulin secretion	8
Frs2-mediated activation	10
Fructose biosynthesis	2
Fructose catabolism	5
Fructose metabolism	7
Fusion and Uncoating of the Influenza Virion	9
Fusion of the Influenza Virion to the Host Cell Endosome	9
G alpha (12/13) signalling events	87
G alpha (i) signalling events	397
G alpha (q) signalling events	212
G alpha (s) signalling events	577
G alpha (z) signalling events	48
G beta:gamma signalling through PI3Kgamma	25
G beta:gamma signalling through PLC beta	20
G protein gated Potassium channels	25
G-protein activation	28
G-protein beta:gamma signalling	28
G-protein mediated events	45
G0 and Early G1	27
G1 Phase	44
G1/S DNA Damage Checkpoints	68
G1/S Transition	131
G1/S-Specific Transcription	28
G2 Phase	5
G2/M Checkpoints	151
G2/M DNA damage checkpoint	78
G2/M DNA replication checkpoint	5
G2/M Transition	197
GAB1 signalosome	11
GABA A (rho) receptor activation	3
GABA A receptor activation	13
GABA B receptor activation	39
GABA receptor activation	55
GABA synthesis	2
GABA synthesis, release, reuptake and degradation	19
GDP-fucose biosynthesis	6
GLI proteins bind promoters of Hh responsive genes to promote transcription	3
GLI3 is processed to GLI3R by the proteasome	60
GP1b-IX-V activation signalling	12
GPCR downstream signalling	1146
GPCR ligand binding	461
GPVI-mediated activation cascade	35
GRB2 events in EGFR signaling	7
GRB2 events in ERBB2 signaling	18
GRB2:SOS provides linkage to MAPK signaling for Integrins	15
GRB7 events in ERBB2 signaling	6
GTP hydrolysis and joining of the 60S ribosomal subunit	113
Galactose catabolism	6
Gamma carboxylation, hypusine formation and arylsulfatase activation	39
Gamma-carboxylation of protein precursors	10
Gamma-carboxylation, transport, and amino-terminal cleavage of proteins	11
Gap junction assembly	37
Gap junction degradation	12
Gap junction trafficking	48
Gap junction trafficking and regulation	50
Gap-filling DNA repair synthesis and ligation in GG-NER	25
Gap-filling DNA repair synthesis and ligation in TC-NER	64
Gastrin-CREB signalling pathway via PKC and MAPK	18
Gene Silencing by RNA	108
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	38
Gene expression (Transcription)	1416
Generation of second messenger molecules	52
Generic Transcription Pathway	1152
Global Genome Nucleotide Excision Repair (GG-NER)	84
Glucagon signaling in metabolic regulation	34
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion	43
Glucagon-type ligand receptors	34
Glucocorticoid biosynthesis	9
Gluconeogenesis	34
Glucose metabolism	96
Glucuronidation	24
Glutamate Neurotransmitter Release Cycle	24
Glutamate binding, activation of AMPA receptors and synaptic plasticity	31
Glutathione conjugation	37
Glutathione synthesis and recycling	13
Glycerophospholipid biosynthesis	129
Glycerophospholipid catabolism	7
Glycine degradation	4
Glycogen breakdown (glycogenolysis)	16
Glycogen metabolism	27
Glycogen storage disease type 0 (liver GYS2)	2
Glycogen storage disease type 0 (muscle GYS1)	2
Glycogen storage disease type II (GAA)	2
Glycogen storage disease type IV (GBE1)	3
Glycogen storage disease type Ia (G6PC)	1
Glycogen storage disease type Ib (SLC37A4)	1
Glycogen storage disease type XV (GYG1)	2
Glycogen storage diseases	16
Glycogen synthesis	16
Glycolysis	76
Glycoprotein hormones	10
Glycosaminoglycan metabolism	124
Glycosphingolipid metabolism	46
Glyoxylate metabolism and glycine degradation	31
Golgi Associated Vesicle Biogenesis	56
Golgi Cisternae Pericentriolar Stack Reorganization	14
Golgi-to-ER retrograde transport	136
Growth hormone receptor signaling	24
HATs acetylate histones	108
HCN channels	4
HDACs deacetylate histones	60
HDL assembly	8
HDL clearance	5
HDL remodeling	11
HDMs demethylate histones	27
HDR through Homologous Recombination (HRR)	66
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)	114
HDR through MMEJ (alt-NHEJ)	10
HDR through Single Strand Annealing (SSA)	37
HHAT G278V abrogates palmitoylation of Hh-Np	4
HIV Infection	246
HIV Life Cycle	163
HIV Transcription Elongation	47
HIV Transcription Initiation	47
HIV elongation arrest and recovery	36
HS-GAG biosynthesis	31
HS-GAG degradation	22
HSF1 activation	12
HSF1-dependent transactivation	24
HSP90 chaperone cycle for steroid hormone receptors (SHR)	56
Hedgehog 'off' state	113
Hedgehog 'on' state	85
Hedgehog ligand biogenesis	65
Heme biosynthesis	11
Heme degradation	6
Hemostasis	723
Heparan sulfate/heparin (HS-GAG) metabolism	55
Hereditary fructose intolerance	1
Hh mutants abrogate ligand secretion	59
Hh mutants that don't undergo autocatalytic processing are degraded by ERAD	56
Highly calcium permeable nicotinic acetylcholine receptors	9
Highly calcium permeable postsynaptic nicotinic acetylcholine receptors	11
Highly sodium permeable acetylcholine nicotinic receptors	7
Histamine receptors	4
Histidine catabolism	8
Histidine, lysine, phenylalanine, tyrosine, proline and tryptophan catabolism	46
Homologous DNA Pairing and Strand Exchange	42
Homology Directed Repair	120
Hormone ligand-binding receptors	13
Host Interactions of HIV factors	142
Host Interactions with Influenza Factors	48
HuR (ELAVL1) binds and stabilizes mRNA	8
Hyaluronan biosynthesis and export	5
Hyaluronan metabolism	17
Hyaluronan uptake and degradation	12
Hydrolysis of LPC	9
Hydrolysis of LPE	2
Hydroxycarboxylic acid-binding receptors	3
Hypusine synthesis from eIF5A-lysine	4
IGF1R signaling cascade	61
IKBKB deficiency causes SCID	3
IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR)	3
IKK complex recruitment mediated by RIP1	23
IL-6-type cytokine receptor ligand interactions	17
IRAK1 recruits IKK complex	14
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation	14
IRAK2 mediated activation of TAK1 complex	10
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation	16
IRAK4 deficiency (TLR2/4)	12
IRAK4 deficiency (TLR5)	5
IRE1alpha activates chaperones	57
IRF3 mediated activation of type 1 IFN	5
IRF3-mediated induction of type I IFN	13
IRS activation	5
IRS-mediated signalling	54
IRS-related events triggered by IGF1R	58
ISG15 antiviral mechanism	78
IkBA variant leads to EDA-ID	7
Immune System	2226
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	297
Import of palmitoyl-CoA into the mitochondrial matrix	14
Inactivation of APC/C via direct inhibition of the APC/C complex	20
Inactivation of CDC42 and RAC1	8
Inactivation, recovery and regulation of the phototransduction cascade	33
Incretin synthesis, secretion, and inactivation	23
Infectious disease	460
Inflammasomes	24
Influenza Infection	169
Influenza Life Cycle	158
Influenza Viral RNA Transcription and Replication	149
Influenza Virus Induced Apoptosis	4
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits	25
Inhibition of Host mRNA Processing and RNA Silencing	3
Inhibition of IFN-beta	1
Inhibition of Interferon Synthesis	1
Inhibition of PKR	2
Inhibition of Signaling by Overexpressed EGFR	2
Inhibition of TSC complex formation by PKB	3
Inhibition of adenylate cyclase pathway	14
Inhibition of replication initiation of damaged DNA by RB1/E2F1	13
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components	20
Initial triggering of complement	111
Initiation of Nuclear Envelope Reformation	14
InlA-mediated entry of Listeria monocytogenes into host cells	10
InlB-mediated entry of Listeria monocytogenes into host cell	16
Innate Immune System	1180
Inositol phosphate metabolism	48
Inositol transporters	3
Insulin effects increased synthesis of Xylulose-5-Phosphate	2
Insulin processing	27
Insulin receptor recycling	26
Insulin receptor signalling cascade	60
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA	3
Integration of energy metabolism	111
Integration of provirus	15
Integration of viral DNA into host genomic DNA	9
Integrin alphaIIb beta3 signaling	28
Integrin cell surface interactions	85
Integrin signaling	28
Interaction With Cumulus Cells	1
Interaction With The Zona Pellucida	10
Interaction between L1 and Ankyrins	31
Interaction between PHLDA1 and AURKA	2
Interactions of Rev with host cellular proteins	40
Interactions of Tat with host cellular proteins	3
Interactions of Vpr with host cellular proteins	45
Interconversion of 2-oxoglutarate and 2-hydroxyglutarate	3
Interconversion of nucleotide di- and triphosphates	30
Interconversion of polyamines	3
Interferon Signaling	284
Interferon alpha/beta signaling	137
Interferon gamma signaling	172
Interleukin receptor SHC signaling	27
Interleukin-1 family signaling	140
Interleukin-1 processing	7
Interleukin-1 signaling	102
Interleukin-10 signaling	45
Interleukin-12 family signaling	57
Interleukin-12 signaling	47
Interleukin-15 signaling	14
Interleukin-17 signaling	71
Interleukin-18 signaling	9
Interleukin-2 family signaling	45
Interleukin-2 signaling	12
Interleukin-20 family signaling	25
Interleukin-21 signaling	10
Interleukin-23 signaling	9
Interleukin-27 signaling	11
Interleukin-3, Interleukin-5 and GM-CSF signaling	48
Interleukin-33 signaling	4
Interleukin-35 Signalling	12
Interleukin-36 pathway	7
Interleukin-37 signaling	21
Interleukin-38 signaling	4
Interleukin-4 and Interleukin-13 signaling	111
Interleukin-6 family signaling	28
Interleukin-6 signaling	15
Interleukin-7 signaling	25
Interleukin-9 signaling	9
Intestinal absorption	5
Intestinal hexose absorption	4
Intestinal infectious diseases	3
Intestinal lipid absorption	1
Intestinal saccharidase deficiencies	2
Intra-Golgi and retrograde Golgi-to-ER traffic	205
Intra-Golgi traffic	44
Intracellular oxygen transport	3
Intracellular signaling by second messengers	300
Intraflagellar transport	53
Intrinsic Pathway for Apoptosis	44
Intrinsic Pathway of Fibrin Clot Formation	22
Invadopodia formation	4
Inwardly rectifying K+ channels	31
Ion channel transport	184
Ion homeostasis	54
Ion influx/efflux at host-pathogen interface	4
Ion transport by P-type ATPases	55
Ionotropic activity of kainate receptors	10
Iron uptake and transport	58
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1	22
Josephin domain DUBs	12
KSRP (KHSRP) binds and destabilizes mRNA	17
Keratan sulfate biosynthesis	28
Keratan sulfate degradation	13
Keratan sulfate/keratin metabolism	34
Keratinization	217
Ketone body metabolism	10
Kinesins	63
L13a-mediated translational silencing of Ceruloplasmin expression	112
L1CAM interactions	120
LDL clearance	19
LDL remodeling	4
LGI-ADAM interactions	14
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production	5
Lactose synthesis	3
Lagging Strand Synthesis	20
Laminin interactions	30
Late Phase of HIV Life Cycle	150
Latent infection of Homo sapiens with Mycobacterium tuberculosis	35
Leading Strand Synthesis	14
Lectin pathway of complement activation	8
Leukotriene receptors	5
Ligand-receptor interactions	8
Linoleic acid (LA) metabolism	8
Lipid particle organization	6
Listeria monocytogenes entry into host cells	22
Localization of the PINCH-ILK-PARVIN complex to focal adhesions	4
Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling	6
Loss of Function of SMAD2/3 in Cancer	7
Loss of Function of SMAD4 in Cancer	3
Loss of Function of TGFBR1 in Cancer	7
Loss of Function of TGFBR2 in Cancer	4
Loss of Nlp from mitotic centrosomes	69
Loss of proteins required for interphase microtubule organization from the centrosome	69
Lysine catabolism	12
Lysosomal oligosaccharide catabolism	4
Lysosome Vesicle Biogenesis	37
Lysosphingolipid and LPA receptors	14
M Phase	370
M/G1 Transition	85
MAP kinase activation	63
MAP2K and MAPK activation	40
MAP3K8 (TPL2)-dependent MAPK1/3 activation	16
MAPK family signaling cascades	302
MAPK targets/ Nuclear events mediated by MAP kinases	31
MAPK1 (ERK2) activation	10
MAPK1/MAPK3 signaling	263
MAPK3 (ERK1) activation	11
MAPK6/MAPK4 signaling	89
MASTL Facilitates Mitotic Progression	10
MET Receptor Activation	6
MET activates PI3K/AKT signaling	6
MET activates PTK2 signaling	30
MET activates PTPN11	5
MET activates RAP1 and RAC1	11
MET activates RAS signaling	11
MET activates STAT3	3
MET interacts with TNS proteins	5
MET promotes cell motility	41
MET receptor recycling	10
MGMT-mediated DNA damage reversal	1
MHC class II antigen presentation	141
MPS I - Hurler syndrome	1
MPS II - Hunter syndrome	1
MPS IIIA - Sanfilippo syndrome A	1
MPS IIIB - Sanfilippo syndrome B	1
MPS IIIC - Sanfilippo syndrome C	1
MPS IIID - Sanfilippo syndrome D	1
MPS IV - Morquio syndrome A	1
MPS IV - Morquio syndrome B	1
MPS IX - Natowicz syndrome	1
MPS VI - Maroteaux-Lamy syndrome	1
MPS VII - Sly syndrome	1
MTF1 activates gene expression	3
Macroautophagy	68
Major pathway of rRNA processing in the nucleolus and cytosol	183
Meiosis	88
Meiotic recombination	56
Meiotic synapsis	60
Melanin biosynthesis	5
Membrane Trafficking	630
Membrane binding and targetting of GAG proteins	15
Metabolic disorders of biological oxidation enzymes	35
Metabolism	2116
Metabolism of Angiotensinogen to Angiotensins	17
Metabolism of RNA	673
Metabolism of amino acids and derivatives	371
Metabolism of carbohydrates	279
Metabolism of cofactors	19
Metabolism of fat-soluble vitamins	48
Metabolism of folate and pterines	18
Metabolism of ingested H2SeO4 and H2SeO3 into H2Se	4
Metabolism of ingested MeSeO2H into MeSeH	1
Metabolism of ingested SeMet, Sec, MeSec into H2Se	8
Metabolism of lipids	746
Metabolism of nitric oxide	15
Metabolism of non-coding RNA	55
Metabolism of nucleotides	103
Metabolism of polyamines	85
Metabolism of porphyrins	17
Metabolism of proteins	2111
Metabolism of serotonin	2
Metabolism of steroid hormones	34
Metabolism of steroids	152
Metabolism of vitamin K	3
Metabolism of vitamins and cofactors	192
Metabolism of water-soluble vitamins and cofactors	126
Metal ion SLC transporters	26
Metal sequestration by antimicrobial proteins	6
Metalloprotease DUBs	31
Metallothioneins bind metals	11
Methionine salvage pathway	6
Methylation	14
Methylation of MeSeH for excretion	1
MicroRNA (miRNA) biogenesis	24
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane	19
Mineralocorticoid biosynthesis	6
Minus-strand DNA synthesis	7
Miscellaneous substrates	12
Miscellaneous transport and binding events	26
Mismatch Repair	15
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)	14
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)	14
Misspliced GSK3beta mutants stabilize beta-catenin	15
Misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling	6
Mitochondrial ABC transporters	4
Mitochondrial Fatty Acid Beta-Oxidation	38
Mitochondrial Uncoupling Proteins	5
Mitochondrial biogenesis	96
Mitochondrial calcium ion transport	23
Mitochondrial iron-sulfur cluster biogenesis	13
Mitochondrial protein import	65
Mitochondrial tRNA aminoacylation	21
Mitochondrial transcription initiation	3
Mitochondrial transcription termination	1
Mitochondrial translation	94
Mitochondrial translation elongation	88
Mitochondrial translation initiation	88
Mitochondrial translation termination	88
Mitophagy	29
Mitotic Anaphase	201
Mitotic G1-G1/S phases	149
Mitotic G2-G2/M phases	199
Mitotic Metaphase and Anaphase	202
Mitotic Metaphase/Anaphase Transition	2
Mitotic Prometaphase	198
Mitotic Prophase	117
Mitotic Spindle Checkpoint	110
Mitotic Telophase/Cytokinesis	14
Molecules associated with elastic fibres	38
Molybdenum cofactor biosynthesis	8
Mtb iron assimilation by chelation	6
Mucopolysaccharidoses	11
Multifunctional anion exchangers	9
Muscarinic acetylcholine receptors	5
Muscle contraction	205
MyD88 cascade initiated on plasma membrane	85
MyD88 deficiency (TLR2/4)	11
MyD88 deficiency (TLR5)	3
MyD88 dependent cascade initiated on endosome	92
MyD88-independent TLR4 cascade	98
MyD88:Mal cascade initiated on plasma membrane	95
Myoclonic epilepsy of Lafora	11
Myogenesis	29
N-Glycan antennae elongation	15
N-glycan antennae elongation in the medial/trans-Golgi	26
N-glycan trimming and elongation in the cis-Golgi	5
N-glycan trimming in the ER and Calnexin/Calreticulin cycle	35
NADE modulates death signalling	6
NADPH regeneration	1
NCAM signaling for neurite out-growth	63
NCAM1 interactions	42
NEP/NS2 Interacts with the Cellular Export Machinery	40
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10	12
NF-kB is activated and signals survival	13
NFG and proNGF binds to p75NTR	3
NGF processing	4
NGF-independant TRKA activation	5
NIK-->noncanonical NF-kB signaling	59
NOD1/2 Signaling Pathway	35
NOSIP mediated eNOS trafficking	2
NOSTRIN mediated eNOS trafficking	5
NOTCH1 Intracellular Domain Regulates Transcription	48
NOTCH2 Activation and Transmission of Signal to the Nucleus	22
NOTCH2 intracellular domain regulates transcription	12
NOTCH3 Activation and Transmission of Signal to the Nucleus	25
NOTCH3 Intracellular Domain Regulates Transcription	25
NOTCH4 Activation and Transmission of Signal to the Nucleus	11
NOTCH4 Intracellular Domain Regulates Transcription	20
NR1D1 (REV-ERBA) represses gene expression	3
NRAGE signals death through JNK	59
NRIF signals cell death from the nucleus	16
NS1 Mediated Effects on Host Pathways	44
NTF3 activates NTRK2 (TRKB) signaling	2
NTF3 activates NTRK3 signaling	2
NTF4 activates NTRK2 (TRKB) signaling	2
NTRK2 activates RAC1	5
NTRK3 as a dependence receptor	3
Na+/Cl- dependent neurotransmitter transporters	19
Nectin/Necl trans heterodimerization	7
Neddylation	236
Nef Mediated CD4 Down-regulation	10
Nef Mediated CD8 Down-regulation	8
Nef and signal transduction	9
Nef mediated downregulation of CD28 cell surface expression	3
Nef mediated downregulation of MHC class I complex cell surface expression	11
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters	22
Negative epigenetic regulation of rRNA expression	78
Negative feedback regulation of MAPK pathway	6
Negative regulation of FGFR1 signaling	35
Negative regulation of FGFR2 signaling	37
Negative regulation of FGFR3 signaling	30
Negative regulation of FGFR4 signaling	31
Negative regulation of MAPK pathway	40
Negative regulation of MET activity	21
Negative regulation of NOTCH4 signaling	55
Negative regulation of TCF-dependent signaling by DVL-interacting proteins	5
Negative regulation of TCF-dependent signaling by WNT ligand antagonists	15
Negative regulation of activity of TFAP2 (AP-2) family transcription factors	11
Negative regulation of the PI3K/AKT network	115
Negative regulators of DDX58/IFIH1 signaling	34
Nephrin family interactions	23
Netrin mediated repulsion signals	8
Netrin-1 signaling	50
Neurexins and neuroligins	60
Neurodegenerative Diseases	23
Neurofascin interactions	7
Neuronal System	370
Neurophilin interactions with VEGF and VEGFR	4
Neurotoxicity of clostridium toxins	22
Neurotransmitter clearance	10
Neurotransmitter receptors and postsynaptic signal transmission	152
Neurotransmitter release cycle	51
Neurotransmitter uptake and metabolism In glial cells	4
Neutrophil degranulation	480
Nicotinamide salvaging	19
Nicotinate metabolism	31
Nitric oxide stimulates guanylate cyclase	25
NoRC negatively regulates rRNA expression	75
Non-integrin membrane-ECM interactions	59
Noncanonical activation of NOTCH3	8
Nonhomologous End-Joining (NHEJ)	52
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	117
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)	96
Nonsense-Mediated Decay (NMD)	117
Norepinephrine Neurotransmitter Release Cycle	18
Notch-HLH transcription pathway	13
NrCAM interactions	7
Nuclear Envelope Breakdown	56
Nuclear Envelope Reassembly	14
Nuclear Events (kinase and transcription factor activation)	25
Nuclear Pore Complex (NPC) Disassembly	38
Nuclear Receptor transcription pathway	84
Nuclear import of Rev protein	37
Nuclear signaling by ERBB4	27
Nucleobase biosynthesis	15
Nucleobase catabolism	39
Nucleosome assembly	54
Nucleotide Excision Repair	110
Nucleotide salvage	23
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways	58
Nucleotide-like (purinergic) receptors	16
O-glycosylation of TSR domain-containing proteins	39
O-linked glycosylation	115
O-linked glycosylation of mucins	66
O2/CO2 exchange in erythrocytes	12
Olfactory Signaling Pathway	432
Oligomerization of connexins into connexons	3
Oncogene Induced Senescence	34
Oncogenic MAPK signaling	77
Opioid Signalling	81
Opsins	9
Orc1 removal from chromatin	71
Orexin and neuropeptides FF and QRFP bind to their respective receptors	8
Organelle biogenesis and maintenance	297
Organic anion transport	5
Organic anion transporters	10
Organic cation transport	10
Organic cation/anion/zwitterion transport	15
Other interleukin signaling	26
Other semaphorin interactions	19
Ovarian tumor domain proteases	38
Oxidative Stress Induced Senescence	94
Oxygen-dependent asparagine hydroxylation of Hypoxia-inducible Factor Alpha	3
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha	66
P2Y receptors	12
PAOs oxidise polyamines to amines	2
PCNA-Dependent Long Patch Base Excision Repair	21
PCP/CE pathway	92
PD-1 signaling	42
PDE3B signalling	2
PECAM1 interactions	12
PERK regulates gene expression	28
PI Metabolism	84
PI and PC transport between ER and Golgi membranes	1
PI-3K cascade:FGFR1	23
PI-3K cascade:FGFR2	26
PI-3K cascade:FGFR3	19
PI-3K cascade:FGFR4	20
PI3K Cascade	50
PI3K events in ERBB2 signaling	18
PI3K events in ERBB4 signaling	11
PI3K/AKT Signaling in Cancer	106
PI3K/AKT activation	9
PI5P Regulates TP53 Acetylation	9
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	108
PIP3 activates AKT signaling	269
PIWI-interacting RNA (piRNA) biogenesis	29
PKA activation	17
PKA activation in glucagon signalling	18
PKA-mediated phosphorylation of CREB	18
PKA-mediated phosphorylation of key metabolic factors	5
PKB-mediated events	2
PKMTs methylate histone lysines	47
PLC beta mediated events	44
PLC-gamma1 signalling	3
PLCG1 events in ERBB2 signaling	4
POLB-Dependent Long Patch Base Excision Repair	8
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation	13
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation	3
PP2A-mediated dephosphorylation of key metabolic factors	7
PPARA activates gene expression	118
PRC2 methylates histones and DNA	42
PTEN Loss of Function in Cancer	1
PTEN Regulation	139
PTK6 Activates STAT3	4
PTK6 Down-Regulation	3
PTK6 Expression	5
PTK6 Regulates Cell Cycle	6
PTK6 Regulates Proteins Involved in RNA Processing	5
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases	14
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1	9
PTK6 promotes HIF1A stabilization	6
Packaging Of Telomere Ends	33
Packaging of Eight RNA Segments	9
Paradoxical activation of RAF signaling by kinase inactive BRAF	41
Passive transport by Aquaporins	13
Pausing and recovery of HIV elongation	36
Pausing and recovery of Tat-mediated HIV elongation	35
Pentose phosphate pathway	15
Pentose phosphate pathway disease	2
Peptide chain elongation	90
Peptide hormone biosynthesis	12
Peptide hormone metabolism	88
Peptide ligand-binding receptors	189
Peroxisomal lipid metabolism	29
Peroxisomal protein import	64
Phase 0 - rapid depolarisation	45
Phase 1 - inactivation of fast Na+ channels	7
Phase 2 - plateau phase	28
Phase 3 - rapid repolarisation	8
Phase 4 - resting membrane potential	19
Phase I - Functionalization of compounds	106
Phase II - Conjugation of compounds	110
Phenylalanine and tyrosine catabolism	11
Phenylketonuria	1
Phosphate bond hydrolysis by NTPDase proteins	8
Phosphate bond hydrolysis by NUDT proteins	10
Phospholipase C-mediated cascade: FGFR1	18
Phospholipase C-mediated cascade; FGFR2	21
Phospholipase C-mediated cascade; FGFR3	14
Phospholipase C-mediated cascade; FGFR4	15
Phospholipid metabolism	212
Phosphorylation of CD3 and TCR zeta chains	41
Phosphorylation of Emi1	6
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes	4
Phosphorylation of proteins involved in the G2/M transition by Cyclin A:Cdc2 complexes	3
Phosphorylation of the APC/C	19
Physiological factors	12
Pink/Parkin Mediated Mitophagy	22
Plasma lipoprotein assembly	19
Plasma lipoprotein assembly, remodeling, and clearance	72
Plasma lipoprotein clearance	33
Plasma lipoprotein remodeling	33
Plasmalogen biosynthesis	2
Platelet Adhesion to exposed collagen	15
Platelet Aggregation (Plug Formation)	40
Platelet activation, signaling and aggregation	262
Platelet calcium homeostasis	28
Platelet degranulation	128
Platelet homeostasis	90
Platelet sensitization by LDL	17
Plus-strand DNA synthesis	7
Polo-like kinase mediated events	16
Polymerase switching	14
Polymerase switching on the C-strand of the telomere	14
Positive epigenetic regulation of rRNA expression	75
Post NMDA receptor activation events	35
Post-chaperonin tubulin folding pathway	22
Post-transcriptional silencing by small RNAs	7
Post-translational modification: synthesis of GPI-anchored proteins	94
Post-translational protein modification	1415
Post-translational protein phosphorylation	107
Postsynaptic nicotinic acetylcholine receptors	14
Potassium Channels	99
Potassium transport channels	3
Pre-NOTCH Expression and Processing	78
Pre-NOTCH Processing in Golgi	18
Pre-NOTCH Processing in the Endoplasmic Reticulum	6
Pre-NOTCH Transcription and Translation	62
Prefoldin mediated transfer of substrate to CCT/TriC	27
Pregnenolone biosynthesis	12
Presynaptic depolarization and calcium channel opening	13
Presynaptic function of Kainate receptors	21
Presynaptic nicotinic acetylcholine receptors	12
Presynaptic phase of homologous DNA pairing and strand exchange	39
Processing and activation of SUMO	10
Processing of Capped Intron-Containing Pre-mRNA	243
Processing of Capped Intronless Pre-mRNA	28
Processing of DNA double-strand break ends	81
Processing of Intronless Pre-mRNAs	19
Processing of SMDT1	16
Processive synthesis on the C-strand of the telomere	11
Processive synthesis on the lagging strand	15
Programmed Cell Death	176
Progressive trimming of alpha-1,2-linked mannose residues from Man9/8/7GlcNAc2 to produce Man5GlcNAc2	3
Prolactin receptor signaling	15
Proline catabolism	3
Prolonged ERK activation events	12
Propionyl-CoA catabolism	5
Prostacyclin signalling through prostacyclin receptor	20
Prostanoid ligand receptors	9
Protein folding	101
Protein methylation	17
Protein repair	6
Protein ubiquitination	79
Protein-protein interactions at synapses	91
Proton-coupled monocarboxylate transport	6
Proton-coupled neutral amino acid transporters	2
Proton/oligopeptide cotransporters	4
Purine catabolism	21
Purine ribonucleoside monophosphate biosynthesis	12
Purine salvage	13
Pyrimidine biosynthesis	3
Pyrimidine catabolism	12
Pyrimidine salvage	11
Pyrophosphate hydrolysis	2
Pyruvate metabolism	31
Pyruvate metabolism and Citric Acid (TCA) cycle	55
RA biosynthesis pathway	22
RAB GEFs exchange GTP for GDP on RABs	90
RAB geranylgeranylation	65
RAF activation	25
RAF-independent MAPK1/3 activation	24
RAF/MAP kinase cascade	256
RAS signaling downstream of NF1 loss-of-function variants	4
RET signaling	41
RHO GTPase Effectors	285
RHO GTPases Activate Formins	140
RHO GTPases Activate NADPH Oxidases	13
RHO GTPases Activate ROCKs	19
RHO GTPases Activate Rhotekin and Rhophilins	9
RHO GTPases Activate WASPs and WAVEs	36
RHO GTPases activate CIT	20
RHO GTPases activate IQGAPs	31
RHO GTPases activate KTN1	11
RHO GTPases activate PAKs	21
RHO GTPases activate PKNs	63
RHO GTPases regulate CFTR trafficking	3
RIP-mediated NFkB activation via ZBP1	17
RIPK1-mediated regulated necrosis	23
RMTs methylate histone arginines	49
RNA Pol II CTD phosphorylation and interaction with CE	27
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection	27
RNA Polymerase I Chain Elongation	59
RNA Polymerase I Promoter Clearance	78
RNA Polymerase I Promoter Escape	30
RNA Polymerase I Promoter Opening	32
RNA Polymerase I Transcription	80
RNA Polymerase I Transcription Initiation	47
RNA Polymerase I Transcription Termination	31
RNA Polymerase II HIV Promoter Escape	47
RNA Polymerase II Pre-transcription Events	84
RNA Polymerase II Promoter Escape	47
RNA Polymerase II Transcription	1274
RNA Polymerase II Transcription Elongation	61
RNA Polymerase II Transcription Initiation	47
RNA Polymerase II Transcription Initiation And Promoter Clearance	47
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening	47
RNA Polymerase II Transcription Termination	66
RNA Polymerase III Abortive And Retractive Initiation	41
RNA Polymerase III Chain Elongation	18
RNA Polymerase III Transcription	41
RNA Polymerase III Transcription Initiation	36
RNA Polymerase III Transcription Initiation From Type 1 Promoter	28
RNA Polymerase III Transcription Initiation From Type 2 Promoter	27
RNA Polymerase III Transcription Initiation From Type 3 Promoter	28
RNA Polymerase III Transcription Termination	23
RNA polymerase II transcribes snRNA genes	74
RNF mutants show enhanced WNT signaling and proliferation	8
ROBO receptors bind AKAP5	9
RORA activates gene expression	18
ROS, RNS production in phagocytes	32
RPIA deficiency: failed conversion of R5P to RU5P	1
RPIA deficiency: failed conversion of RU5P to R5P	1
RSK activation	6
RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)	10
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known	37
RUNX1 regulates estrogen receptor mediated transcription	6
RUNX1 regulates expression of components of tight junctions	5
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function	66
RUNX1 regulates transcription of genes involved in BCR signaling	6
RUNX1 regulates transcription of genes involved in WNT signaling	6
RUNX1 regulates transcription of genes involved in differentiation of HSCs	99
RUNX1 regulates transcription of genes involved in differentiation of keratinocytes	8
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells	8
RUNX1 regulates transcription of genes involved in interleukin signaling	5
RUNX2 regulates bone development	32
RUNX2 regulates chondrocyte maturation	6
RUNX2 regulates genes involved in cell migration	9
RUNX2 regulates genes involved in differentiation of myeloid cells	5
RUNX2 regulates osteoblast differentiation	25
RUNX3 Regulates Immune Response and Cell Migration	6
RUNX3 regulates BCL2L11 (BIM) transcription	5
RUNX3 regulates CDKN1A transcription	7
RUNX3 regulates NOTCH signaling	14
RUNX3 regulates RUNX1-mediated transcription	2
RUNX3 regulates WNT signaling	8
RUNX3 regulates YAP1-mediated transcription	8
RUNX3 regulates p14-ARF	9
Rab regulation of trafficking	123
Rap1 signalling	16
Ras activation upon Ca2+ influx through NMDA receptor	17
Reactions specific to the complex N-glycan synthesis pathway	10
Reactions specific to the hybrid N-glycan synthesis pathway	1
Receptor Mediated Mitophagy	11
Receptor-type tyrosine-protein phosphatases	20
Recognition and association of DNA glycosylase with site containing an affected purine	4
Recognition and association of DNA glycosylase with site containing an affected pyrimidine	8
Recognition of DNA damage by PCNA-containing replication complex	31
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks	59
Recruitment of NuMA to mitotic centrosomes	94
Recruitment of mitotic centrosome proteins and complexes	81
Recycling of bile acids and salts	16
Recycling of eIF2:GDP	8
Recycling pathway of L1	48
Reduction of cytosolic Ca++ levels	12
Reelin signalling pathway	5
Regulated Necrosis	23
Regulated proteolysis of p75NTR	11
Regulation by TREX1	1
Regulation by c-FLIP	11
Regulation of APC/C activators between G1/S and early anaphase	80
Regulation of Apoptosis	53
Regulation of Complement cascade	135
Regulation of FZD by ubiquitination	21
Regulation of Glucokinase by Glucokinase Regulatory Protein	34
Regulation of HSF1-mediated heat shock response	73
Regulation of Hypoxia-inducible Factor (HIF) by oxygen	75
Regulation of IFNA signaling	26
Regulation of IFNG signaling	14
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)	124
Regulation of KIT signaling	16
Regulation of PAK-2p34 activity by PS-GAP/RHG10	2
Regulation of PLK1 Activity at G2/M Transition	87
Regulation of PTEN gene transcription	60
Regulation of PTEN localization	9
Regulation of PTEN mRNA translation	9
Regulation of PTEN stability and activity	69
Regulation of RAS by GAPs	68
Regulation of RUNX1 Expression and Activity	17
Regulation of RUNX2 expression and activity	74
Regulation of RUNX3 expression and activity	55
Regulation of TLR by endogenous ligand	19
Regulation of TNFR1 signaling	37
Regulation of TP53 Activity	160
Regulation of TP53 Activity through Acetylation	30
Regulation of TP53 Activity through Association with Co-factors	14
Regulation of TP53 Activity through Methylation	19
Regulation of TP53 Activity through Phosphorylation	92
Regulation of TP53 Degradation	36
Regulation of TP53 Expression	2
Regulation of TP53 Expression and Degradation	37
Regulation of actin dynamics for phagocytic cup formation	150
Regulation of activated PAK-2p34 by proteasome mediated degradation	50
Regulation of beta-cell development	44
Regulation of cholesterol biosynthesis by SREBP (SREBF)	56
Regulation of commissural axon pathfinding by SLIT and ROBO	10
Regulation of cortical dendrite branching	4
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components	8
Regulation of expression of SLITs and ROBOs	172
Regulation of gap junction activity	3
Regulation of gene expression by Hypoxia-inducible Factor	11
Regulation of gene expression in beta cells	23
Regulation of gene expression in early pancreatic precursor cells	8
Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells	5
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells	16
Regulation of innate immune responses to cytosolic DNA	15
Regulation of insulin secretion	81
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)	120
Regulation of mRNA stability by proteins that bind AU-rich elements	88
Regulation of mitotic cell cycle	86
Regulation of necroptotic cell death	21
Regulation of ornithine decarboxylase (ODC)	51
Regulation of pyruvate dehydrogenase (PDH) complex	16
Regulation of signaling by CBL	22
Regulation of signaling by NODAL	12
Regulation of thyroid hormone activity	3
Relaxin receptors	8
Release	9
Release of Hh-Np from the secreting cell	8
Release of apoptotic factors from the mitochondria	4
Removal of aminoterminal propeptides from gamma-carboxylated proteins	10
Removal of the Flap Intermediate	14
Removal of the Flap Intermediate from the C-strand	10
Repression of WNT target genes	12
Reproduction	114
Resolution of AP sites via the multiple-nucleotide patch replacement pathway	25
Resolution of AP sites via the single-nucleotide replacement pathway	4
Resolution of Abasic Sites (AP sites)	39
Resolution of D-Loop Structures	33
Resolution of D-loop Structures through Holliday Junction Intermediates	32
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)	26
Resolution of Sister Chromatid Cohesion	125
Respiratory electron transport	101
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.	124
Response of Mtb to phagocytosis	35
Response to elevated platelet cytosolic Ca2+	133
Response to metal ions	14
Retinoid cycle disease events	13
Retinoid metabolism and transport	44
Retinoid metabolism disease events	1
Retrograde neurotrophin signalling	14
Retrograde transport at the Trans-Golgi-Network	49
Reuptake of GABA	4
Rev-mediated nuclear export of HIV RNA	38
Reversal of alkylation damage by DNA dioxygenases	7
Reverse Transcription of HIV RNA	7
Reversible hydration of carbon dioxide	12
Rhesus glycoproteins mediate ammonium transport.	3
Rho GTPase cycle	141
Ribosomal scanning and start codon recognition	59
Role of ABL in ROBO-SLIT signaling	8
Role of LAT2/NTAL/LAB on calcium mobilization	102
Role of phospholipids in phagocytosis	114
Role of second messengers in netrin-1 signaling	10
S Phase	161
S33 mutants of beta-catenin aren't phosphorylated	15
S37 mutants of beta-catenin aren't phosphorylated	15
S45 mutants of beta-catenin aren't phosphorylated	15
SCF(Skp2)-mediated degradation of p27/p21	60
SCF-beta-TrCP mediated degradation of Emi1	55
SDK interactions	2
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion	14
SHC-mediated cascade:FGFR1	24
SHC-mediated cascade:FGFR2	27
SHC-mediated cascade:FGFR3	20
SHC-mediated cascade:FGFR4	21
SHC-related events triggered by IGF1R	11
SHC1 events in EGFR signaling	8
SHC1 events in ERBB2 signaling	27
SHC1 events in ERBB4 signaling	16
SIRT1 negatively regulates rRNA expression	37
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs	11
SLBP independent Processing of Histone Pre-mRNAs	10
SLC transporter disorders	68
SLC-mediated transmembrane transport	246
SLIT2:ROBO1 increases RHOA activity	4
SMAC binds to IAPs	5
SMAC-mediated apoptotic response	5
SMAC-mediated dissociation of IAP:caspase complexes	5
SMAD2/3 MH2 Domain Mutants in Cancer	7
SMAD2/3 Phosphorylation Motif Mutants in Cancer	6
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription	32
SMAD4 MH2 Domain Mutants in Cancer	3
SOS-mediated signalling	7
SRP-dependent cotranslational protein targeting to membrane	113
STAT6-mediated induction of chemokines	3
STING mediated induction of host immune responses	16
SUMO E3 ligases SUMOylate target proteins	172
SUMO is conjugated to E1 (UBA2:SAE1)	5
SUMO is proteolytically processed	6
SUMO is transferred from E1 to E2 (UBE2I, UBC9)	7
SUMOylation	178
SUMOylation of DNA damage response and repair proteins	79
SUMOylation of DNA methylation proteins	16
SUMOylation of DNA replication proteins	48
SUMOylation of RNA binding proteins	49
SUMOylation of SUMOylation proteins	37
SUMOylation of chromatin organization proteins	60
SUMOylation of immune response proteins	11
SUMOylation of intracellular receptors	31
SUMOylation of transcription cofactors	44
SUMOylation of transcription factors	20
SUMOylation of ubiquitinylation proteins	41
Scavenging by Class A Receptors	19
Scavenging by Class B Receptors	6
Scavenging by Class F Receptors	7
Scavenging by Class H Receptors	4
Scavenging of heme from plasma	99
SeMet incorporation into proteins	11
Selenoamino acid metabolism	118
Selenocysteine synthesis	94
Sema3A PAK dependent Axon repulsion	16
Sema4D in semaphorin signaling	24
Sema4D induced cell migration and growth-cone collapse	20
Sema4D mediated inhibition of cell attachment and migration	8
Semaphorin interactions	64
Senescence-Associated Secretory Phenotype (SASP)	79
Sensing of DNA Double Strand Breaks	6
Separation of Sister Chromatids	189
Serine biosynthesis	9
Serotonin Neurotransmitter Release Cycle	18
Serotonin and melatonin biosynthesis	5
Serotonin clearance from the synaptic cleft	3
Serotonin receptors	12
Severe congenital neutropenia type 4 (G6PC3)	1
Sialic acid metabolism	33
Signal Transduction	2738
Signal amplification	32
Signal attenuation	10
Signal regulatory protein family interactions	16
Signal transduction by L1	21
Signaling by Activin	13
Signaling by BMP	28
Signaling by BRAF and RAF fusions	61
Signaling by EGFR	44
Signaling by EGFR in Cancer	19
Signaling by EGFRvIII in Cancer	15
Signaling by ERBB2	55
Signaling by ERBB4	47
Signaling by FGFR	94
Signaling by FGFR in disease	72
Signaling by FGFR1	53
Signaling by FGFR1 amplification mutants	2
Signaling by FGFR1 in disease	40
Signaling by FGFR2	77
Signaling by FGFR2 IIIa TM	23
Signaling by FGFR2 amplification mutants	2
Signaling by FGFR2 fusions	1
Signaling by FGFR2 in disease	48
Signaling by FGFR3	42
Signaling by FGFR3 fusions in cancer	10
Signaling by FGFR3 in disease	24
Signaling by FGFR3 point mutants in cancer	24
Signaling by FGFR4	42
Signaling by FGFR4 in disease	11
Signaling by GPCR	1209
Signaling by Hedgehog	149
Signaling by Hippo	20
Signaling by Insulin receptor	84
Signaling by Interleukins	457
Signaling by Leptin	11
Signaling by Ligand-Responsive EGFR Variants in Cancer	19
Signaling by MET	79
Signaling by MST1	5
Signaling by NODAL	21
Signaling by NOTCH	205
Signaling by NOTCH1	74
Signaling by NOTCH1 HD Domain Mutants in Cancer	15
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer	59
Signaling by NOTCH1 PEST Domain Mutants in Cancer	59
Signaling by NOTCH1 in Cancer	59
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant	7
Signaling by NOTCH2	33
Signaling by NOTCH3	49
Signaling by NOTCH4	83
Signaling by NTRK1 (TRKA)	79
Signaling by NTRK2 (TRKB)	26
Signaling by NTRK3 (TRKC)	18
Signaling by NTRKs	103
Signaling by Non-Receptor Tyrosine Kinases	57
Signaling by Nuclear Receptors	169
Signaling by Overexpressed Wild-Type EGFR in Cancer	2
Signaling by PDGF	59
Signaling by PTK6	57
Signaling by RAS mutants	54
Signaling by ROBO receptors	218
Signaling by Receptor Tyrosine Kinases	471
Signaling by Retinoic Acid	43
Signaling by Rho GTPases	416
Signaling by SCF-KIT	44
Signaling by TGF-beta Receptor Complex	73
Signaling by TGF-beta Receptor Complex in Cancer	8
Signaling by TGF-beta family members	102
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	62
Signaling by VEGF	106
Signaling by WNT	297
Signaling by WNT in cancer	34
Signaling by activated point mutants of FGFR1	12
Signaling by activated point mutants of FGFR3	14
Signaling by cytosolic FGFR1 fusion mutants	18
Signaling by high-kinase activity BRAF mutants	36
Signaling by moderate kinase activity BRAF mutants	41
Signaling by plasma membrane FGFR1 fusions	3
Signaling by the B Cell Receptor (BCR)	180
Signalling to ERK5	2
Signalling to ERKs	32
Signalling to RAS	20
Signalling to STAT3	3
Signalling to p38 via RIT and RIN	5
Small interfering RNA (siRNA) biogenesis	9
Smooth Muscle Contraction	35
Sodium-coupled phosphate cotransporters	5
Sodium-coupled sulphate, di- and tri-carboxylate transporters	5
Sodium/Calcium exchangers	11
Sodium/Proton exchangers	9
Sperm Motility And Taxes	9
Sperm:Oocyte Membrane Binding	5
Sphingolipid de novo biosynthesis	44
Sphingolipid metabolism	90
Spry regulation of FGF signaling	16
Stabilization of p53	57
Sterols are 12-hydroxylated by CYP8B1	2
Stimulation of the cell death response by PAK-2p34	2
Stimuli-sensing channels	107
Striated Muscle Contraction	36
Sulfide oxidation to sulfate	6
Sulfur amino acid metabolism	27
Surfactant metabolism	30
Switching of origins to a post-replicative state	90
Synaptic adhesion-like molecules	21
Syndecan interactions	27
Synthesis And Processing Of GAG, GAGPOL Polyproteins	15
Synthesis and processing of ENV and VPU	3
Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE)	9
Synthesis of 12-eicosatetraenoic acid derivatives	7
Synthesis of 15-eicosatetraenoic acid derivatives	6
Synthesis of 5-eicosatetraenoic acids	9
Synthesis of CL	1
Synthesis of DNA	119
Synthesis of Dolichyl-phosphate	6
Synthesis of GDP-mannose	5
Synthesis of Hepoxilins (HX) and Trioxilins (TrX)	1
Synthesis of IP2, IP, and Ins in the cytosol	14
Synthesis of IP3 and IP4 in the cytosol	26
Synthesis of IPs in the ER lumen	1
Synthesis of IPs in the nucleus	4
Synthesis of Ketone Bodies	8
Synthesis of Leukotrienes (LT) and Eoxins (EX)	21
Synthesis of Lipoxins (LX)	6
Synthesis of PA	39
Synthesis of PC	28
Synthesis of PE	13
Synthesis of PG	8
Synthesis of PI	5
Synthesis of PIPs at the ER membrane	5
Synthesis of PIPs at the Golgi membrane	18
Synthesis of PIPs at the early endosome membrane	16
Synthesis of PIPs at the late endosome membrane	11
Synthesis of PIPs at the plasma membrane	53
Synthesis of PIPs in the nucleus	4
Synthesis of PS	2
Synthesis of Prostaglandins (PG) and Thromboxanes (TX)	15
Synthesis of UDP-N-acetyl-glucosamine	8
Synthesis of active ubiquitin: roles of E1 and E2 enzymes	30
Synthesis of bile acids and bile salts	34
Synthesis of bile acids and bile salts via 24-hydroxycholesterol	14
Synthesis of bile acids and bile salts via 27-hydroxycholesterol	15
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol	24
Synthesis of diphthamide-EEF2	8
Synthesis of dolichyl-phosphate mannose	3
Synthesis of dolichyl-phosphate-glucose	2
Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET)	8
Synthesis of glycosylphosphatidylinositol (GPI)	18
Synthesis of pyrophosphates in the cytosol	10
Synthesis of substrates in N-glycan biosythesis	63
Synthesis of very long-chain fatty acyl-CoAs	24
Synthesis of wybutosine at G37 of tRNA(Phe)	6
Synthesis, secretion, and deacylation of Ghrelin	20
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)	20
Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)	13
T41 mutants of beta-catenin aren't phosphorylated	15
TAK1 activates NFkB by phosphorylation and activation of IKKs complex	32
TALDO1 deficiency: failed conversion of Fru(6)P, E4P to SH7P, GA3P	1
TALDO1 deficiency: failed conversion of SH7P, GA3P to Fru(6)P, E4P	1
TBC/RABGAPs	45
TCF dependent signaling in response to WNT	202
TCF7L2 mutants don't bind CTBP	3
TCR signaling	137
TET1,2,3 and TDG demethylate DNA	4
TFAP2 (AP-2) family regulates transcription of cell cycle factors	5
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors	13
TFAP2 (AP-2) family regulates transcription of other transcription factors	4
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation	5
TGF-beta receptor signaling activates SMADs	32
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)	16
TGFBR1 KD Mutants in Cancer	7
TGFBR1 LBD Mutants in Cancer	4
TGFBR2 Kinase Domain Mutants in Cancer	4
TGFBR2 MSI Frameshift Mutants in Cancer	2
TICAM1 deficiency - HSE	2
TICAM1, RIP1-mediated IKK complex recruitment	19
TICAM1,TRAF6-dependent induction of TAK1 complex	16
TICAM1-dependent activation of IRF3/IRF7	12
TLR3 deficiency - HSE	1
TLR3-mediated TICAM1-dependent programmed cell death	6
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway	17
TNF signaling	47
TNFR1-induced NFkappaB signaling pathway	30
TNFR1-induced proapoptotic signaling	14
TNFR1-mediated ceramide production	6
TNFR2 non-canonical NF-kB pathway	102
TNFs bind their physiological receptors	30
TP53 Regulates Metabolic Genes	88
TP53 Regulates Transcription of Caspase Activators and Caspases	12
TP53 Regulates Transcription of Cell Cycle Genes	49
TP53 Regulates Transcription of Cell Death Genes	44
TP53 Regulates Transcription of DNA Repair Genes	65
TP53 Regulates Transcription of Death Receptors and Ligands	12
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release	20
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest	14
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest	18
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain	21
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain	14
TRAF3 deficiency - HSE	3
TRAF3-dependent IRF activation pathway	14
TRAF6 mediated IRF7 activation	28
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling	14
TRAF6 mediated NF-kB activation	24
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation	91
TRAF6-mediated induction of TAK1 complex within TLR4 complex	17
TRAIL signaling	8
TRIF(TICAM1)-mediated TLR4 signaling	98
TRIF-mediated programmed cell death	9
TRKA activation by NGF	3
TRP channels	28
TWIK related potassium channel (TREK)	3
TWIK-related alkaline pH activated K+ channel (TALK)	2
TWIK-related spinal cord K+ channel (TRESK)	1
TWIK-releated acid-sensitive K+ channel (TASK)	2
TYSND1 cleaves peroxisomal proteins	7
Tachykinin receptors bind tachykinins	5
Tandem of pore domain in a weak inwardly rectifying K+ channels (TWIK)	3
Tandem pore domain halothane-inhibited K+ channel (THIK)	1
Tandem pore domain potassium channels	12
Tat-mediated HIV elongation arrest and recovery	35
Tat-mediated elongation of the HIV-1 transcript	47
Telomere C-strand (Lagging Strand) Synthesis	24
Telomere C-strand synthesis initiation	8
Telomere Extension By Telomerase	6
Telomere Maintenance	63
Terminal pathway of complement	8
Termination of O-glycan biosynthesis	26
Termination of translesion DNA synthesis	32
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation	10
The AIM2 inflammasome	3
The IPAF inflammasome	5
The NLRP1 inflammasome	3
The NLRP3 inflammasome	16
The activation of arylsulfatases	13
The canonical retinoid cycle in rods (twilight vision)	23
The citric acid (TCA) cycle and respiratory electron transport	175
The fatty acid cycling model	5
The phototransduction cascade	34
The proton buffering model	5
The retinoid cycle in cones (daylight vision)	7
The role of GTSE1 in G2/M progression after G2 checkpoint	78
The role of Nef in HIV-1 replication and disease pathogenesis	29
Threonine catabolism	5
Thrombin signalling through proteinase activated receptors (PARs)	32
Thromboxane signalling through TP receptor	23
Thyroxine biosynthesis	10
Tie2 Signaling	18
Tight junction interactions	30
Tolerance by Mtb to nitric oxide produced by macrophages	13
Tolerance of reactive oxygen produced by macrophages	11
Toll Like Receptor 10 (TLR10) Cascade	85
Toll Like Receptor 2 (TLR2) Cascade	98
Toll Like Receptor 3 (TLR3) Cascade	97
Toll Like Receptor 4 (TLR4) Cascade	129
Toll Like Receptor 5 (TLR5) Cascade	85
Toll Like Receptor 7/8 (TLR7/8) Cascade	92
Toll Like Receptor 9 (TLR9) Cascade	96
Toll Like Receptor TLR1:TLR2 Cascade	98
Toll Like Receptor TLR6:TLR2 Cascade	95
Toll-Like Receptors Cascades	155
Toxicity of botulinum toxin type A (BoNT/A)	9
Toxicity of botulinum toxin type B (BoNT/B)	8
Toxicity of botulinum toxin type C (BoNT/C)	4
Toxicity of botulinum toxin type D (BoNT/D)	6
Toxicity of botulinum toxin type E (BoNT/E)	5
Toxicity of botulinum toxin type F (BoNT/F)	6
Toxicity of botulinum toxin type G (BoNT/G)	4
Toxicity of tetanus toxin (TeNT)	2
Trafficking and processing of endosomal TLR	13
Trafficking of AMPA receptors	31
Trafficking of GluR2-containing AMPA receptors	17
Trafficking of myristoylated proteins to the cilium	5
Transcription from mitochondrial promoters	4
Transcription of E2F targets under negative control by DREAM complex	19
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1	16
Transcription of the HIV genome	74
Transcription-Coupled Nucleotide Excision Repair (TC-NER)	78
Transcriptional activation of cell cycle inhibitor p21	4
Transcriptional Regulation by E2F6	34
Transcriptional Regulation by TP53	367
Transcriptional activation of mitochondrial biogenesis	57
Transcriptional activation of p53 responsive genes	4
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer	44
Transcriptional regulation by RUNX1	208
Transcriptional regulation by RUNX2	121
Transcriptional regulation by RUNX3	96
Transcriptional regulation by small RNAs	78
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors	37
Transcriptional regulation of pluripotent stem cells	36
Transcriptional regulation of white adipocyte differentiation	84
Transfer of LPS from LBP carrier to CD14	2
Transferrin endocytosis and recycling	31
Translation	294
Translation initiation complex formation	59
Translesion Synthesis by POLH	19
Translesion synthesis by POLI	17
Translesion synthesis by POLK	17
Translesion synthesis by REV1	16
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template	39
Translocation of SLC2A4 (GLUT4) to the plasma membrane	71
Translocation of ZAP-70 to Immunological synapse	38
Transmission across Chemical Synapses	223
Transmission across Electrical Synapses	5
Transport and synthesis of PAPS	6
Transport of HA trimer, NA tetramer and M2 tetramer from the endoplasmic reticulum to the Golgi Apparatus	3
Transport of Mature Transcript to Cytoplasm	85
Transport of Mature mRNA Derived from an Intronless Transcript	44
Transport of Mature mRNA derived from an Intron-Containing Transcript	76
Transport of Mature mRNAs Derived from Intronless Transcripts	45
Transport of Ribonucleoproteins into the Host Nucleus	38
Transport of bile salts and organic acids, metal ions and amine compounds	86
Transport of connexins along the secretory pathway	3
Transport of connexons to the plasma membrane	20
Transport of fatty acids	8
Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus	9
Transport of glycerol from adipocytes to the liver by Aquaporins	2
Transport of inorganic cations/anions and amino acids/oligopeptides	107
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane	7
Transport of nucleotide sugars	9
Transport of organic anions	12
Transport of small molecules	726
Transport of the SLBP Dependant Mature mRNA	38
Transport of the SLBP independent Mature mRNA	37
Transport of vitamins, nucleosides, and related molecules	39
Transport to the Golgi and subsequent modification	185
Triglyceride biosynthesis	14
Triglyceride catabolism	24
Triglyceride metabolism	38
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA	17
Truncations of AMER1 destabilize the destruction complex	14
Tryptophan catabolism	14
Type I hemidesmosome assembly	11
Type II Na+/Pi cotransporters	3
UCH proteinases	96
UNC93B1 deficiency - HSE	2
Ub-specific processing proteases	205
Ubiquinol biosynthesis	8
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A	53
Ubiquitin-dependent degradation of Cyclin D	52
Ubiquitin-dependent degradation of Cyclin D1	52
Unblocking of NMDA receptor, glutamate binding and activation	17
Uncoating of the HIV Virion	8
Uncoating of the Influenza Virion	9
Unfolded Protein Response (UPR)	95
Unwinding of DNA	12
Uptake and actions of bacterial toxins	48
Uptake and function of anthrax toxins	16
Uptake and function of diphtheria toxin	7
Urea cycle	10
Utilization of Ketone Bodies	4
VEGF binds to VEGFR leading to receptor dimerization	8
VEGF ligand-receptor interactions	8
VEGFA-VEGFR2 Pathway	97
VEGFR2 mediated cell proliferation	19
VEGFR2 mediated vascular permeability	27
VLDL assembly	5
VLDL clearance	6
VLDLR internalisation and degradation	12
Variant SLC6A14 may confer susceptibility towards obesity	1
Variant SLC6A20 contributes towards hyperglycinuria (HG) and iminoglycinuria (IG)	1
Variant SLC6A20 contributes towards hyperglycinuria (HG) and iminoglycinuria (IG)	1
Vasopressin regulates renal water homeostasis via Aquaporins	44
Vasopressin-like receptors	6
Vesicle-mediated transport	756
Vif-mediated degradation of APOBEC3G	56
Viral Messenger RNA Synthesis	50
Viral RNP Complexes in the Host Cell Nucleus	7
Viral mRNA Translation	101
Virus Assembly and Release	11
Visual phototransduction	100
Vitamin B1 (thiamin) metabolism	5
Vitamin B2 (riboflavin) metabolism	7
Vitamin B5 (pantothenate) metabolism	17
Vitamin C (ascorbate) metabolism	8
Vitamin D (calciferol) metabolism	11
Vitamin E	1
Vitamins	6
Vitamins B6 activation to pyridoxal phosphate	3
Voltage gated Potassium channels	43
Vpr-mediated induction of apoptosis by mitochondrial outer membrane permeabilization	4
Vpr-mediated nuclear import of PICs	42
Vpu mediated degradation of CD4	53
VxPx cargo-targeting to cilium	21
WNT ligand biogenesis and trafficking	26
WNT ligand secretion is abrogated by the PORCN inhibitor LGK974	1
WNT mediated activation of DVL	8
WNT5A-dependent internalization of FZD2, FZD5 and ROR2	13
WNT5A-dependent internalization of FZD4	15
Wax biosynthesis	4
XAV939 inhibits tankyrase, stabilizing AXIN	2
XBP1(S) activates chaperone genes	55
Xenobiotics	23
YAP1- and WWTR1 (TAZ)-stimulated gene expression	16
ZBP1(DAI) mediated induction of type I IFNs	21
Zinc efflux and compartmentalization by the SLC30 family	7
Zinc influx into cells by the SLC39 gene family	10
Zinc transporters	17
activated TAK1 mediates p38 MAPK activation	23
alpha-linolenic (omega3) and linoleic (omega6) acid metabolism	13
alpha-linolenic acid (ALA) metabolism	13
betaKlotho-mediated ligand binding	3
c-src mediated regulation of Cx43 function and closure of gap junctions	3
cGMP effects	18
cRNA Synthesis	4
eNOS activation	11
eNOS activation and regulation	15
mRNA 3'-end processing	57
mRNA Capping	29
mRNA Editing	10
mRNA Editing: A to I Conversion	2
mRNA Editing: C to U Conversion	8
mRNA Splicing	188
mRNA Splicing - Major Pathway	180
mRNA Splicing - Minor Pathway	52
mRNA decay by 3' to 5' exoribonuclease	16
mRNA decay by 5' to 3' exoribonuclease	15
mTOR signalling	40
mTORC1-mediated signalling	23
mitochondrial fatty acid beta-oxidation of saturated fatty acids	11
mitochondrial fatty acid beta-oxidation of unsaturated fatty acids	6
p130Cas linkage to MAPK signaling for integrins	15
p38MAPK events	13
p53-Dependent G1 DNA Damage Response	66
p53-Dependent G1/S DNA damage checkpoint	66
p53-Independent DNA Damage Response	53
p53-Independent G1/S DNA damage checkpoint	53
p75 NTR receptor-mediated signalling	99
p75NTR negatively regulates cell cycle via SC1	6
p75NTR recruits signalling complexes	14
p75NTR regulates axonogenesis	10
p75NTR signals via NF-kB	17
phospho-PLA2 pathway	2
phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex	15
rRNA modification in the mitochondrion	6
rRNA modification in the nucleus and cytosol	60
rRNA processing	203
rRNA processing in the mitochondrion	10
rRNA processing in the nucleus and cytosol	193
snRNP Assembly	55
t(4;14) translocations of FGFR3	1
tRNA Aminoacylation	42
tRNA modification in the mitochondrion	9
tRNA modification in the nucleus and cytosol	43
tRNA processing	111
tRNA processing in the mitochondrion	5
tRNA processing in the nucleus	60
trans-Golgi Network Vesicle Budding	74
truncated APC mutants destabilize the destruction complex	14
vRNA Synthesis	4
vRNP Assembly	6
via Death Receptors in the presence of ligand	19
via Dependence Receptors in the absence of ligand	10